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250508s2025 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202416410
|2 doi
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|a pubmed25n1383.xml
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|a DE-627
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|e rakwb
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|a eng
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|a Lin, Zhang
|e verfasserin
|4 aut
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|a Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration
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|c 2025
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 23.04.2025
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|a Date Revised 23.04.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2025 Wiley‐VCH GmbH.
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|a The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically. Stable and highly efficient PtNi nanochains and PtNi nanocages electrocatalysts with anti-interference properties catalyze glucose oxidation and oxygen reduction respectively in an encapsulation-free fuel cell. The laser-induced graphene (LIG) electrode loaded with PtNi electrocatalysts is transferred to the surface of a flexible chitosan hydrogel. The resulting flexible FCP can adapt to tissues with different morphologies, firmly adhere to prevent suturing, and provide potent electrostimulation (0.403 V, 51.55 µW cm-2). Additionally, it consumes oxygen in situ to create a hypoxic microenvironment, increasing the expression of hypoxia-inducible factor-1α (HIF-1α). Based on the different pattern requirements of exogenous electrostimulation during the repair of various types of tissue, an axial FCP for peripheral nerves and a flower-patterned FCP for myocardial tissue are constructed and transplanted into animals, showing significant tissue repair in both models
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|a Journal Article
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|a fuel cells
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|a hydrogels
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|a patterned electrostimulation
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|a tissue repair
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|a Graphite
|2 NLM
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|a 7782-42-5
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|a Chitosan
|2 NLM
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|a 9012-76-4
|2 NLM
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|a Hypoxia-Inducible Factor 1, alpha Subunit
|2 NLM
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|a Nickel
|2 NLM
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|a 7OV03QG267
|2 NLM
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|a Oxygen
|2 NLM
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|a S88TT14065
|2 NLM
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|a Hydrogels
|2 NLM
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| 700 |
1 |
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|a Wu, Yifan
|e verfasserin
|4 aut
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|a Wang, Yuqi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Peipei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xiaolin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zou, Yang
|e verfasserin
|4 aut
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|a Chen, Kangbo
|e verfasserin
|4 aut
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|a Li, Yaping
|e verfasserin
|4 aut
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| 700 |
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|a Zhou, Jinfeng
|e verfasserin
|4 aut
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| 700 |
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|a Ye, Tingting
|e verfasserin
|4 aut
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| 700 |
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|a Qi, Yiying
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Wei
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 37(2025), 16 vom: 13. Apr., Seite e2416410
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:37
|g year:2025
|g number:16
|g day:13
|g month:04
|g pages:e2416410
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|u http://dx.doi.org/10.1002/adma.202416410
|3 Volltext
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