Biomimetic rhCOL17-P334 Conjugate for Enhanced Wound Healing

Détails bibliographiques
Publié dans:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 37(2025), 15 vom: 01. Apr., Seite e2417980
Auteur principal:	Lou, Yijie (Auteur)
Autres auteurs:	Dai, Chunyan, Feng, Shuting, Jin, Rijuan, Liu, Shuangshuang, Zhou, Zhanyi, Wang, Minjun, Yang, Yang, Xu, Guoqiao, Hou, Jue, Chen, Jiayi, Tang, Guping, Wang, Nan, Bai, Hongzhen, Chen, Zhe
Format:	Article en ligne
Langue:	English
Publié:	2025
Accès à la collection:	Advanced materials (Deerfield Beach, Fla.)
Sujets:	Journal Article UVA shielding biomimetic scaffolds collagen XVII porphyra‐334 wound healing Collagen 9007-34-5 Hydrogels Recombinant Proteins plus... Gelatin 9000-70-8 gelatin methacryloyl Methacrylates

Description
Résumé:	© 2025 Wiley‐VCH GmbH. Wound healing remains a significant global health challenge, affecting millions annually and imposing substantial economic burdens. Most commercially available biomaterials for wound management primarily address external symptoms, including hemostasis, exudation, scarring, and infection. Advanced biomaterials derived from endogenous molecules aim to better replicate the native wound microenvironment, promoting enhanced repair. Since wounds frequently occur on exposed skin, which is vulnerable to UVA radiation and requires protective yet invisible materials, traditional wound care products often lack these essential features. Inspired by natural UV protection mechanisms, a novel bioscaffold is developed using recombinant human collagen XVII (rhCOL17) crosslinked with porphyra-334 (P334) to improve wound healing under UVA exposure. The resulting rhCOL17-P334 conjugate integrates extracellular matrix (ECM)-like cues with UVA-shielding properties provided by P334. This conjugate is used to construct a transparent, injectable hydrogel combining gelatin methacryloyl (GelMA) and rhCOL17-P334 (GCP). GCP significantly inhibits UVA-induced fibroblast senescence and improves wound healing outcomes by targeting integrin α6β4 through rhCOL17. Its transparency facilitates convenient wound monitoring while also addressing the aesthetic requirement for invisibility. By combining UVA shielding with wound repair capabilities, GCP presents a promising platform for advanced wound management
Description:	Date Completed 17.04.2025 Date Revised 17.04.2025 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202417980