Single-cell transcriptomics reveals the alteration of immune cell profile in peripheral blood of Henoch-Schonlein purpura
Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 272(2025) vom: 01. März, Seite 110443 |
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| Weitere Verfasser: | , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2025
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
| Schlagworte: | Journal Article Henoch–Schönlein purpura Immune response Peripheral blood mononuclear cell Single-cell RNA sequencing |
| Zusammenfassung: | Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved. Henoch-Schönlein purpura (HSP) is an autoimmune vasculitis affecting multiple organs, and the understanding of circulating immune cell types and their states associated with disease subtypes of HSP remains incomplete. Here, we performed a comprehensive assessment of peripheral blood mononuclear cells of healthy donors and HSP patients, using both single-cell RNA sequencing and multiparameter flow cytometry. We revealed that HSP patients exhibited broad immune activation, evidenced by increased proportions of Effector memory CD8+ T, CD14+ monocytes, Tfh, Th2, Th17, Plasma, and B cells and decreased proportions of Naïve CD4+ T, Treg, Th1, and NK cells. Notably, we identified that cytotoxic effector T cell subsets were enriched in skin and renal type of HSP, whereas Plasma, B, and Tfh cells were expanded in joint and abdominal type of HSP. In conclusion, our findings highlight the dynamic nature of immune responses throughout the progression of HSP with different clinical manifestations |
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| Beschreibung: | Date Completed 07.05.2025 Date Revised 07.05.2025 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2025.110443 |