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250507s2025 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202420171
|2 doi
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|a pubmed25n1397.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Luo, Qiang
|e verfasserin
|4 aut
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|a Myocardia-Injected Synergistically Anti-Apoptotic and Anti-Inflammatory Poly(amino acid) Hydrogel Relieves Ischemia-Reperfusion Injury
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|c 2025
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 06.05.2025
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|a Date Revised 06.05.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2025 Wiley‐VCH GmbH.
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|a Reperfusion therapy is the most effective treatment for acute myocardial infarction, but its efficacy is frequently limited by ischemia-reperfusion injury (IRI). While antioxidant and anti-inflammatory therapies have shown significant potential in alleviating IRI, these strategies have not yielded satisfactory clinical outcomes. For that, a thermo-sensitive myocardial-injectable poly(amino acid) hydrogel of methoxy poly(ethylene glycol)45-poly(L-methionine20-co-L-alanine10) (mPEG45-P(Met20-co-Ala10), PMA) loaded with FTY720 (PMA/FTY720) is developed to address IRI through synergistic anti-apoptotic and anti-inflammatory effects. Upon injection into the ischemic myocardium, the PMA aqueous solution undergoes a sol-to-gel phase transition and gradually degrades in response to reactive oxygen species (ROS), releasing FTY720 on demand. PMA acts synergistically with FTY720 to inhibit cardiomyocyte apoptosis and modulate pro-inflammatory M1 macrophage polarization toward anti-inflammatory M2 macrophages by clearing ROS, thereby mitigating the inflammatory response and promoting vascular regeneration. In a rat IRI model, PMA/FTY720 reduces the apoptotic cell ratio by 81.8%, increases vascular density by 34.0%, and enhances left ventricular ejection fraction (LVEF) by 12.8%. In a rabbit IRI model, the gel-based sustained release of FTY720 enhanced LVEF by an additional 7.2% compared to individual treatment. In summary, the engineered PMA hydrogel effectively alleviates IRI through synergistic anti-apoptosis and anti-inflammation actions, offering valuable clinical potential for treating myocardial IRI
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|a Journal Article
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|a in situ myocardial injection
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|a anti‐apoptosis
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|a anti‐inflammation
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|a ischemia‐reperfusion injury therapy
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|a poly(amino acid) hydrogel
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|a Hydrogels
|2 NLM
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|a Anti-Inflammatory Agents
|2 NLM
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|a Fingolimod Hydrochloride
|2 NLM
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|a G926EC510T
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a Polyethylene Glycols
|2 NLM
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|a 3WJQ0SDW1A
|2 NLM
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| 650 |
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|a Amino Acids
|2 NLM
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| 700 |
1 |
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|a Li, Zhibo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Guoliang
|e verfasserin
|4 aut
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| 700 |
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|a Yao, Haochen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Guoqing
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Bin
|e verfasserin
|4 aut
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|a Ding, Jianxun
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 37(2025), 11 vom: 31. März, Seite e2420171
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:37
|g year:2025
|g number:11
|g day:31
|g month:03
|g pages:e2420171
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|u http://dx.doi.org/10.1002/adma.202420171
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