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250507s2025 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202410559
|2 doi
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|a pubmed25n1392.xml
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|a eng
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|a Wang, Liu
|e verfasserin
|4 aut
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|a Phytochlorin-Based Sonosensitizers Combined with Free-Field Ultrasound for Immune-Sonodynamic Cancer Therapy
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|c 2025
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 01.05.2025
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|a Date Revised 01.05.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2025 Wiley‐VCH GmbH.
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|a Phytochlorins, a class of plant-derived tetrapyrroles, show great potential as sonosensitizers in sonodynamic therapy (SDT). The development of new phytochlorin-based sonosensitizers has significantly improved SDT, yet the absence of specialized sonodynamic systems limits their clinical translation. Herein, a dedicated ultrasound system along with a detailed step-by-step sonodynamic process from in vitro to in vivo is developed to activate phytochlorin-based sonosensitizers. Compared to standing-wave ultrasound, free-field ultrasound maintains stable acoustic pressure amplitudes and minimizes mechanical damage to cell membranes. In vitro experiments demonstrate that free-field ultrasound effectively activates naturally occurring phytochlorin, reducing the cavitation threshold for reactive oxygen species production and triggering immunogenic cell death. Furthermore, the intravenously injectable phytochlorin-based sonosensitizer (C34) enhances sonodynamic efficiency by reducing interfacial tension. Driven by in vivo free-field ultrasound, C34 effectively inhibits tumor growth in an orthotopic murine breast cancer model and elicits an immune response, preventing tumor metastasis. The reliable protocol provided by the free-field ultrasound system facilitates the activation of phytochlorin-based sonosensitizers while simultaneously stimulating the immune system, highlighting the potential of immune-sonodynamic therapy
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|a Journal Article
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|a antitumor
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|a free‐field ultrasound
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|a immune
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|a sonodynamic therapy
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|a sonosensitizer
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|a Chlorophyllides
|2 NLM
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| 650 |
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|a phytochlorin
|2 NLM
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|a 5S2CCF3T1Z
|2 NLM
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| 650 |
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|a Porphyrins
|2 NLM
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| 650 |
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|a Reactive Oxygen Species
|2 NLM
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| 650 |
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|a Antineoplastic Agents
|2 NLM
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| 700 |
1 |
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|a Cao, Lei
|e verfasserin
|4 aut
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| 700 |
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|a Shao, Kun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Jiangan
|e verfasserin
|4 aut
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| 700 |
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|a Li, Guangzhe
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Chao
|e verfasserin
|4 aut
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|a Li, Qing
|e verfasserin
|4 aut
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1 |
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|a Sun, Jing
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Hongjie
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Kai
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Weijie
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 37(2025), 8 vom: 22. Feb., Seite e2410559
|w (DE-627)NLM098206397
|x 1521-4095
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|g volume:37
|g year:2025
|g number:8
|g day:22
|g month:02
|g pages:e2410559
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|u http://dx.doi.org/10.1002/adma.202410559
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