|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM38229632X |
| 003 |
DE-627 |
| 005 |
20250509165044.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
250102s2025 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/acs.langmuir.4c03752
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1391.xml
|
| 035 |
|
|
|a (DE-627)NLM38229632X
|
| 035 |
|
|
|a (NLM)39743662
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Zafar, Farhan
|e verfasserin
|4 aut
|
| 245 |
1 |
2 |
|a A Target Responsive Metal Organic Framework Derived Bimetallic Apta-Switch for Reagentless Molecular Recognition
|
| 264 |
|
1 |
|c 2025
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 29.04.2025
|
| 500 |
|
|
|a Date Revised 29.04.2025
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a By integrating iron-cobalt squarate bimetallic metal-organic framework (Fe-Co-SqBMoF) based smart material (SM) with functional DNA (fDNA), we designed a target responsive fDNAFe-Co-SqBMoF bioelectrode that exhibits recognition induced switchable response to serve as a reagentless single step electrochemical apta-switch (REA). The construct takes advantage of fDNA ability to bind and concentrate target on the receptor interface, while Fe-Co-SqBMoF@SM multifeatures to serve as an immobilization matrix and a signal generating electrochemical switch. Fe-Co-SqBMoF was introduced to prepare a redox active pencil graphite electrode (PGE), while fDNA (aptamer) was decorated on the receptor PGE to impart specificity and selectivity. The Fe-Co-SqBMoF synthesis was characterized through X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, micro-Raman spectroscopy, dynamic light scattering (DLS), and UV-visible (UV-vis) analysis, while each step of fDNA decoration and bioelectrode fabrication was characterized via field emission scanning electron microscopy (FE-SEM), static water contact angle measurements, cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). To explore the potential application of the fDNA@Fe-Co-SqBMoF bioelectrode, we designed a REA for detection of aflatoxin B1 (AFB1) which permitted the detection of AFB1 in the linear range 0.7-1000 pg/mL with an LOD of 0.54 pg. The practical applicability of an fDNA@Fe-Co-SqBMoF based REA was demonstrated in milk and water samples
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
7 |
|a Metal-Organic Frameworks
|2 NLM
|
| 650 |
|
7 |
|a Aptamers, Nucleotide
|2 NLM
|
| 650 |
|
7 |
|a Iron
|2 NLM
|
| 650 |
|
7 |
|a E1UOL152H7
|2 NLM
|
| 650 |
|
7 |
|a DNA
|2 NLM
|
| 650 |
|
7 |
|a 9007-49-2
|2 NLM
|
| 650 |
|
7 |
|a Cobalt
|2 NLM
|
| 650 |
|
7 |
|a 3G0H8C9362
|2 NLM
|
| 650 |
|
7 |
|a Aflatoxin B1
|2 NLM
|
| 650 |
|
7 |
|a 9N2N2Y55MH
|2 NLM
|
| 700 |
1 |
|
|a Saif, Khansa
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Andreescu, Daniel
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Andreescu, Silvana
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hayat, Akhtar
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 41(2025), 1 vom: 14. Jan., Seite 507-517
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
|
| 773 |
1 |
8 |
|g volume:41
|g year:2025
|g number:1
|g day:14
|g month:01
|g pages:507-517
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/acs.langmuir.4c03752
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 41
|j 2025
|e 1
|b 14
|c 01
|h 507-517
|