Critical Role of Nanomaterial Mechanical Properties in Drug Delivery, Nanovaccines and Beyond
© 2024 Wiley‐VCH GmbH.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - 37(2025), 7 vom: 15. Feb., Seite e2413779 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2025
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article Review drug delivery mechanical properties nanomedicines nanoparticles nanovaccines Vaccines Drug Carriers Nanovaccines |
| Zusammenfassung: | © 2024 Wiley‐VCH GmbH. Nanomaterials have become essential in the daily lives, finding applications in food, skincare, drugs, and vaccines. Traditionally, the surface chemistry of nanoparticles (NPs) is considered the key factor in determining their interactions with biological systems. However, recent studies have shown that the mechanical properties of nanomaterials are equally important in regulating nano-bio interactions, though they have often been overlooked. Tuning the mechanical properties of nanomaterials and designing them for biomedical applications is thus crucial. This review begins by discussing the various mechanical cues in biological processes, including how viruses and cells adjust their mechanical properties throughout their life cycles. Basic concepts and terminology related to NP mechanical properties are introduced. Next, five different groups of nanomaterials with tunable mechanical properties are explored. The review then examines the impact of NP mechanical properties on their interactions in vitro and in vivo, covering tumor-targeted drug delivery, nanovaccines, and emerging applications such as oral and intranasal drug delivery. Current challenges in the field and perspectives on future developments are also provided |
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| Beschreibung: | Date Completed 29.04.2025 Date Revised 29.04.2025 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.202413779 |