Ligand Inter-Relation Analysis Via Graph Theory Predicts Macrophage Response

Détails bibliographiques
Publié dans:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 37(2025), 10 vom: 15. März, Seite e2414356
Auteur principal:	Kang, Nayeon (Auteur)
Autres auteurs:	Hwang, Jangsun, Jeong, Daun, Choi, Ji Hye, Thangam, Ramar, Min, Sunhong, Hong, Hyunsik, Kim, Dahee, Rha, Hyunji, Lee, Sungkyu, Jung, Hwapyung, Kim, Taeeon, Zare, Iman, Jung, Hee Joon, Najafabadi, Alireza Hassani, Jung, Hyun-Do, Zhang, Kunyu, Zhao, Pengchao, Bian, Liming, Kim, Hong-Kyu, Kim, Jong Seung, Song, Guosheng, Yoon, Juyoung, Park, Sung-Gyu, Jang, Woo Young, Kang, Heemin
Format:	Article en ligne
Langue:	English
Publié:	2025
Accès à la collection:	Advanced materials (Deerfield Beach, Fla.)
Sujets:	Journal Article Graph theory RGD graph RGD nano inter‐relation macrophage regulation remote manipulation arginyl-glycyl-aspartic acid 78VO7F77PN Ligands Oligopeptides Integrins

Description
Résumé:	© 2024 Wiley‐VCH GmbH. Graph theory has been widely used to quantitatively analyze complex networks of molecules, materials, and cells. Analyzing the dynamic complex structure of extracellular matrix can predict cell-material interactions but has not yet been demonstrated. In this study, graph theory-based mathematical modeling of RGD ligand graph inter-relation is demonstrated by differentially cutting off RGD-to-RGD interlinkages with flexibly conjugated magnetic nanobars (MNBs) with tunable aspect ratio. The RGD-to-RGD interlinkages are less effectively cut off by MNBs with a lower aspect ratio, which decreases the shortest path while increasing the number of instances thereof, thereby augmenting RGD nano inter-relation. This facilitates integrin recruitment of macrophages and thus actin fiber assembly and vinculin expression, which mediates pro-regenerative polarization, involving myosin II, actin polymerization, and rho-associated protein kinase. Unidirectional pre-aligning or reversibly lifting highly elongated MNBs both increase RGD nano inter-relation, which promotes host macrophage adhesion and switches their polarization from pro-inflammatory to pro-regenerative phenotype. The latter approach produces nano-spaces through which macrophages can penetrate and establish RGD links thereunder. Using graph theory, this study presents the example of mathematically modeling the functionality of extracellular-matrix-mimetic materials, which can help elucidate complex dynamics of the interactions occurring between host cells and materials via versatile geometrical nano-engineering
Description:	Date Completed 28.04.2025 Date Revised 28.04.2025 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202414356