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241223s2025 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202415656
|2 doi
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|a pubmed25n1389.xml
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|a (NLM)39713947
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Zhang, Hongyu
|e verfasserin
|4 aut
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|a Renal Clearable Chiral Manganese Oxide Supraparticles for In Vivo Detection of Metalloproteinase-9 in Early Cancer Diagnosis
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|c 2025
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 29.04.2025
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|a Date Revised 29.04.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a In this study, polypeptide TGGGPLGVARGKGGC-induced chiral manganese dioxide supraparticles (MnO2 SPs) are prepared for sensitive quantification of matrix metalloproteinase-9 (MMP-9) in vitro and in vivo. The results show that L-type manganese dioxide supraparticles (L-MnO2 SPs) exhibited twice the affinity for the cancer cell membrane receptor CD47 (cluster of differentiation, integrin-associated protein) than D-type manganese dioxide supraparticles (D-MnO2 SPs) to accumulate at the tumor site after surface modification of the internalizing arginine-glycine-aspartic acid (iRGD) ligand, specifically reacting with the MMP-9, disassembling into ultrasmall nanoparticles (NPs), and efficiently underwent renal clearance. Furthermore, L-MnO2 facilitates the quantification of MMP-9 in mouse tumor xenografts, as demonstrated by circular dichroism (CD) and magnetic resonance imaging (MRI) within 2 h. A strong linear relationship is observed between MMP-9 concentration and both CD and MRI intensity, ranging from 0.01 to 10 ng mL-1. The corresponding limits of detection (LOD) are 0.0054 ng mL-1 for CD and 0.0062 ng mL-1 for MRI, respectively. hese SPs provide a new approach for exploring chiral advanced biosensors for early diagnosis of cancer
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|a Journal Article
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|a chirality
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|a magnetic resonance imaging
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|a manganese oxide
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|a matrix metalloproteinase 9
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|a supraparticles
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|a Manganese Compounds
|2 NLM
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|a Matrix Metalloproteinase 9
|2 NLM
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| 650 |
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7 |
|a EC 3.4.24.35
|2 NLM
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| 650 |
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7 |
|a Oxides
|2 NLM
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| 650 |
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7 |
|a manganese oxide
|2 NLM
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| 650 |
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7 |
|a 64J2OA7MH3
|2 NLM
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| 650 |
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|a manganese dioxide
|2 NLM
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| 650 |
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|a TF219GU161
|2 NLM
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| 700 |
1 |
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|a Chen, Panpan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Wenxiong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qu, Aihua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Maozhong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kuang, Hua
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 37(2025), 7 vom: 03. Feb., Seite e2415656
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
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|g volume:37
|g year:2025
|g number:7
|g day:03
|g month:02
|g pages:e2415656
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|u http://dx.doi.org/10.1002/adma.202415656
|3 Volltext
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