Predesign of Covalent-Organic Frameworks for Efficient Photocatalytic Dehydrogenative Cross-Coupling Reaction
© 2024 Wiley‐VCH GmbH.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - (2024) vom: 23. Dez., Seite e2413638 |
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| Weitere Verfasser: | , , , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2024
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article covalent‐organic frameworks pharmaceutical synthesis photocatalyst |
| Zusammenfassung: | © 2024 Wiley‐VCH GmbH. The dehydrogenative cross-coupling reaction is the premier route for synthesizing important 4-quinazolinone drugs. However, it usually requires high reaction temperature and long reaction time, and the yield of the final product is low. Here two stable and photosensitive covalent-organic frameworks (COFs), TAPP-An and TAPP-Cu-An are purposefully designed and constructed to serve as unprecedented heterogeneous tandem catalysts to complete dehydrogenative cross-coupling reactions in a short time and under mild reaction conditions (room temperature and light), leading to the high-efficient photosynthesis of 4-quinazolinones. Particularly, TAPP-Cu-An is the best heterogeneous catalyst currently available for the synthesis of 4-quinazolinones, even surpassing all the catalysts reported so far. It also enables one-step photosynthesis of 4-quinazolinones with higher conversion (>99%) and selectivity (>99%) in a shorter time, and the product can be easily prepared on a gram scale. Extensive experiments combined with theoretical calculations show that the excellent photogenerated charge separation and transport capability, as well as the synergistic An-Cu catalysis in TAPP-Cu-An are the main driving forces for this efficient reaction |
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| Beschreibung: | Date Revised 23.12.2024 published: Print-Electronic Citation Status Publisher |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.202413638 |