A Novel Deer Antler-Inspired Bone Graft Triggers Rapid Bone Regeneration

A Novel Deer Antler-Inspired Bone Graft Triggers Rapid Bone Regeneration

© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - (2024) vom: 20. Dez., Seite e2411571
1. Verfasser: Li, Shengyou (VerfasserIn)
Weitere Verfasser: Yang, Yujie, Yu, Beibei, Gao, Xueli, Gao, Xue, Nie, Shihao, Qin, Tao, Hao, Yiming, Guo, Lingli, Wu, Haining, Ma, Teng, Zheng, Yi, Geng, Dan, Gao, Jianbo, Xue, Borui, Zhang, Yongfeng, Yang, Shijie, Wei, Yitao, Xia, Bing, Luo, Zhuojing, Qiu, Qiang, Huang, Jinghui
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article angiogenesis antler‐based bone graft bioinspiration bone regeneration neurogenesis
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520 |a Adult mammals are unable to regenerate bulky bone tissues, making large bone defects clinically challenging. Deer antler represents an exception to this rule, exhibiting the fastest bony growth in mammals, offering a unique opportunity to explore novel strategies for rapid bone regeneration. Here, a bone graft exploiting the biochemical, biophysical, and structural characteristics of antlers is constructed. It is decellularized antler cancellous bone (antler-DCB) to obtain a bone scaffold. Then, an antler-based bone graft is constructed by integrating antler-DCB with antler-derived biological signals, delivered by extracellular vesicles (EVs) from antler blastema progenitor cells (ABPCs), a novel stem cells responsible for antlerogenesis is discovered. The antler-based bone graft transformed bone marrow stromal cells into cells with an ABPC-like phenotype and transcriptomic signature. In vivo, the antler-based graft triggered rapid bone formation in a rat model, with doubled volume of newly formed bones than commercial DCBs. In addition, the antler-based graft orchestrated a coordinated process of vascularization, neurogenesis, and immunomodulation during osteogenesis, partially imitating early antlerogenesis. These findings provide practical insights to develop a therapeutic intervention for treating severe bone defects 
650 4 |a Journal Article 
650 4 |a angiogenesis 
650 4 |a antler‐based bone graft 
650 4 |a bioinspiration 
650 4 |a bone regeneration 
650 4 |a neurogenesis 
700 1 |a Yang, Yujie  |e verfasserin  |4 aut 
700 1 |a Yu, Beibei  |e verfasserin  |4 aut 
700 1 |a Gao, Xueli  |e verfasserin  |4 aut 
700 1 |a Gao, Xue  |e verfasserin  |4 aut 
700 1 |a Nie, Shihao  |e verfasserin  |4 aut 
700 1 |a Qin, Tao  |e verfasserin  |4 aut 
700 1 |a Hao, Yiming  |e verfasserin  |4 aut 
700 1 |a Guo, Lingli  |e verfasserin  |4 aut 
700 1 |a Wu, Haining  |e verfasserin  |4 aut 
700 1 |a Ma, Teng  |e verfasserin  |4 aut 
700 1 |a Zheng, Yi  |e verfasserin  |4 aut 
700 1 |a Geng, Dan  |e verfasserin  |4 aut 
700 1 |a Gao, Jianbo  |e verfasserin  |4 aut 
700 1 |a Xue, Borui  |e verfasserin  |4 aut 
700 1 |a Zhang, Yongfeng  |e verfasserin  |4 aut 
700 1 |a Yang, Shijie  |e verfasserin  |4 aut 
700 1 |a Wei, Yitao  |e verfasserin  |4 aut 
700 1 |a Xia, Bing  |e verfasserin  |4 aut 
700 1 |a Luo, Zhuojing  |e verfasserin  |4 aut 
700 1 |a Qiu, Qiang  |e verfasserin  |4 aut 
700 1 |a Huang, Jinghui  |e verfasserin  |4 aut 
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