Reinforcing Gelatin Hydrogels via In Situ Phase Separation and Enhanced Interphase Bonding for Advanced 3D Fabrication

Reinforcing Gelatin Hydrogels via In Situ Phase Separation and Enhanced Interphase Bonding for Advanced 3D Fabrication

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - (2024) vom: 10. Dez., Seite e2416432
1. Verfasser: Ren, Chunling (VerfasserIn)
Weitere Verfasser: Chen, Wanqi, Liao, Yun, Huang, Yangguang, Yu, Changlong, Chen, Ting, Zeng, Qingmei, Yang, Yunlong, Huang, Rongkun, Liu, Tuan, Jiang, Li, Bao, Bingkun, Zhu, Linyong, Lin, Qiuning
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article 3D printing biomaterials gelatin hydrogels mechanical performance tissue engineering
Beschreibung
Zusammenfassung:© 2024 Wiley‐VCH GmbH.
Gelatin hydrogels (e.g., methacrylated gelatin gel, abbreviated GelMA gel) have garnered significant attention in tissue engineering and therapeutic drug and cell delivery due to their complete degradability and intrinsic ability to support cell adhesion. However, their practical applications are often constrained by their poor mechanical performance, which stems from their single network structure. This limitation poses significant challenges in load-bearing scenarios and restricts their use in advanced biofabrication technologies, where robust mechanical properties are essential. Here a hydrogel is developed composed entirely of gelatin using a phototriggered transient-radical and persistent-radical coupling (PTPC) reaction to achieve an optimized microstructure. This hydrogel features a phase-separated structure with enhanced interfacial bonding, significantly improving mechanical performance compared to conventional GelMA gels. Notably, this approach preserves the inherent properties of gelatin, including biocompatibility, cell adhesion, and degradability, thereby extending its applicability in the biomedical field, particularly in advanced biofabrication methods such as 3D printing. This approach offers a superior solution to meet the complex demands of sophisticated biomanufacturing technologies, expanding the potential applications of gelatin hydrogels in the biomedical field
Beschreibung:Date Revised 11.12.2024
published: Print-Electronic
Citation Status Publisher
ISSN:1521-4095
DOI:10.1002/adma.202416432