Adaptable Hydrogel with Strong Adhesion of Wet Tissue for Long-Term Protection of Periodontitis Wound
© 2024 Wiley‐VCH GmbH.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - (2024) vom: 20. Nov., Seite e2413373 |
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| Weitere Verfasser: | , , , , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2024
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article hydrogels in situ light‐curing periodontitis wet adhesion wound protection |
| Zusammenfassung: | © 2024 Wiley‐VCH GmbH. Periodontitis is a severe gum infection characterized by inflammation of the tissues surrounding the teeth. The disease is challenging to manage due to its exposure to a wet and dynamic oral environment, where conventional hydrogels often suffer from weak adhesion, short residence time, and vulnerability to bacterial invasion. In this study, an innovative hydrogel system based on in situ light curing is proposed. The hydrogel precursor, comprising sodium alginate and a calcium ion network, is designed and adhere to the irregular and smooth surfaces of periodontal tissue before curing. Upon light irradiation, a second network polymerizes rapidly, establishing multiple interactions with the tissue, which enhances adhesion strength. Benefited from this engineering strategy, the hydrogel exhibits a low swelling rate, effectively mitigating adhesion loss in the moist oral environment. Additionally, the hydrogel demonstrates excellent long-lasting wet adhesion, maintaining its presence in periodontal tissue over 120 hours. It also serves as an effective physical barrier against bacterial invasion, achieving a blocking efficiency of 99.9%. This novel design concept offers a promising approach for developing advanced medical dressings for periodontitis, providing sustained therapeutic benefits |
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| Beschreibung: | Date Revised 21.11.2024 published: Print-Electronic Citation Status Publisher |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.202413373 |