HLA evolutionary divergence effect on bacterial infection risk in cirrhotic liver transplant candidates

HLA evolutionary divergence effect on bacterial infection risk in cirrhotic liver transplant candidates

Copyright © 2024. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 270(2024) vom: 19. Jan., Seite 110399
1. Verfasser: Mazzola, Alessandra (VerfasserIn)
Weitere Verfasser: Roger, Clémentine, Lhotte, Romain, Mallet, Maxime, Thabut, Dominique, Taupin, Jean-Luc, Conti, Filomena
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2025
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Bacterial infections Cirrhosis Cirrhosis decompensation HLA evolutionary divergence Liver transplantation HLA Antigens
Beschreibung
Zusammenfassung:Copyright © 2024. Published by Elsevier Inc.
Bacterial infections are common in cirrhosis patients, increasing the risk of decompensation and death. The impact of HLA evolutionary divergence (HED) on infection risk hasn't been studied in humans before. We conducted a retrospective study on cirrhosis patients awaiting liver transplantation (LT) from January 2019 to February 2022, examining class I and II-HED effects on bacterial infections and cirrhosis decompensation. We included 269 cirrhosis patients. Among them, 98 experienced 153 bacterial infections. Multivariable analysis after variable selection revealed that higher class II-HED was linked to fewer bacterial infections (p = 0.034), while class I-HED showed no effect (p = 0.074). Independent risk factors for bacterial infections included invasive procedures (p < 0.001), ICU hospitalization (p < 0.001), recent antibiotic treatment (p = 0.046), rifaximin use (p = 0.043), and cirrhosis decompensation (p = 0.002). Neither class I nor II-HED affected decompensation risk. This pioneering study shows that high class II-HED levels may protect against bacterial infections in cirrhosis patients awaiting LT, suggesting an immunological mechanism at play
Beschreibung:Date Completed 10.12.2024
Date Revised 10.12.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2024.110399