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|a 10.1093/jxb/erae469
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|a eng
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|a Lee, Juhyeon
|e verfasserin
|4 aut
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|a Phytochrome-interacting factors PIF4 and PIF5 directly regulate autophagy during leaf senescence in Arabidopsis
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|c 2024
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Revised 16.11.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For commercial re-use, please contact reprintsoup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
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|a During leaf senescence, autophagy plays a critical role by removing damaged cellular components and participating in nutrient remobilization to sink organs. However, how AUTOPHGAY (ATG) genes are regulated during natural leaf senescence remains largely unknown. In this study, we attempted to identify upstream transcriptional regulator(s) of ATGs and their molecular basis during leaf senescence in Arabidopsis through the combined analyses of promoter binding, autophagy flux, and genetic interactions. We found that PIF4 and PIF5 (PIF4/PIF5) directly bind to the promoters of the ATG5, ATG12a, ATG12b, ATG8a, ATG8e, ATG8f, and ATG8g, inducing their transcription. These target ATGs are downregulated in pif4, pif5, and pif4pif5 mutants, resulting in decreased autophagic activity and slower degradation of chloroplast proteins and chlorophyll. Conversely, overexpression of ATG8s accelerated protein degradation with early leaf senescence. Moreover, our data suggests partial suppression of the pif4pif5 phenotype by ATG8a overexpression. PIF4/PIF5 also influences senescence induced by nutrient starvation, another hallmark of the autophagy pathway. Furthermore, we observed that the PIF4/PIF5-ATG regulatory module may contribute to seed maturation. Our study not only unveils transcriptional regulators of autophagy in natural leaf senescence but also underscores the potential role of PIF4/PIF5 as functional regulators in leaf senescence and nutrient remobilization
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|a Journal Article
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|a Autophagy
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|a Leaf senescence
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|a Nutrient remobilization
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|a Phytochrome-interacting factor
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|a Starvation
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|a Transcriptions Factors
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|a Kang, Myeong Hoon
|e verfasserin
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|a Choi, Da-Min
|e verfasserin
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|a Marmagne, Anne
|e verfasserin
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|a Park, Jeehye
|e verfasserin
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|a Lee, Heeho
|e verfasserin
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|a Gwak, Eunha
|e verfasserin
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|a Lee, Jong Chan
|e verfasserin
|4 aut
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|a Kim, Jeong-Il
|e verfasserin
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|a Masclaux-Daubresse, Céline
|e verfasserin
|4 aut
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|a Lim, Pyung Ok
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g (2024) vom: 16. Nov.
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|x 1460-2431
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|g day:16
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|u http://dx.doi.org/10.1093/jxb/erae469
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