Centromeres are hotspots for chromosomal inversions and breeding traits in mango

Centromeres are hotspots for chromosomal inversions and breeding traits in mango

© 2024 State of Queensland. New Phytologist © 2024 New Phytologist Foundation.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 245(2025), 2 vom: 15. Jan., Seite 899-913
1. Verfasser: Wilkinson, Melanie J (VerfasserIn)
Weitere Verfasser: McLay, Kathleen, Kainer, David, Elphinstone, Cassandra, Dillon, Natalie L, Webb, Matthew, Wijesundara, Upendra K, Ali, Asjad, Bally, Ian S E, Munyengwa, Norman, Furtado, Agnelo, Henry, Robert J, Hardner, Craig M, Ortiz-Barrientos, Daniel
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2025
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Mangifera indica (mango) centromeric regions chromosomal inversions deleterious alleles local PCA low‐recombination regions plant breeding structural variation
Beschreibung
Zusammenfassung:© 2024 State of Queensland. New Phytologist © 2024 New Phytologist Foundation.
Chromosomal inversions can preserve combinations of favorable alleles by suppressing recombination. Simultaneously, they reduce the effectiveness of purifying selection enabling deleterious alleles to accumulate. This study explores how areas of low recombination, including centromeric regions and chromosomal inversions, contribute to the accumulation of deleterious and favorable loci in 225 Mangifera indica genomes from the Australian Mango Breeding Program. Here, we identify 17 chromosomal inversions that cover 7.7% (29.7 Mb) of the M. indica genome: eight pericentric (inversion includes the centromere) and nine paracentric (inversion is on one arm of the chromosome). Our results show that these large pericentric inversions are accumulating deleterious loci, while the paracentric inversions show deleterious levels above and below the genome wide average. We find that despite their deleterious load, chromosomal inversions contain small effect loci linked to variation in crucial breeding traits. These results indicate that chromosomal inversions have likely facilitated the evolution of key mango breeding traits. Our study has important implications for selective breeding of favorable combinations of alleles in regions of low recombination
Beschreibung:Date Completed 19.12.2024
Date Revised 19.12.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1469-8137
DOI:10.1111/nph.20252