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241116s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.4c03206
|2 doi
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|a pubmed24n1613.xml
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|a eng
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|a Zhang, Xu
|e verfasserin
|4 aut
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| 245 |
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|a Antimicrobial GL13K Peptide-Decorated ZnO Nanoparticles To Treat Bacterial Infections
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 26.11.2024
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|a Date Revised 26.11.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a As a broad-spectrum antimicrobial material, ZnO nanoparticles (NPs) offer a novel approach to infected wounds in the clinic; however, it is very necessary to improve the antimicrobial performance of ZnO to satisfy the clinic requirements. In this work, a new antimicrobial hybrid ZnOPDA/GL13K was prepared by attaching the antimicrobial GL13K peptide on the surface of ZnO NPs via polydopamine (PDA) as a covalent bonding agent, which can enhance the reactive oxygen species (ROS) production and damage the cell wall, showing superior antimicrobial efficacy. Besides, the ZnO@PDA/GL13K hybrid can promote the healing of bacterial infected wounds, with the wound area only remaining 1.8% on day 9, about 2 times smaller than that of the ZnO group. Moreover, ZnO@PDA/GL13K also showed good biocompatibility, and no side effect on normal tissue and organs was found, implying that the antimicrobial hybrid may possess prospective application in biomedical fields
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|a Journal Article
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|a Zinc Oxide
|2 NLM
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|a SOI2LOH54Z
|2 NLM
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|a Anti-Bacterial Agents
|2 NLM
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|a Indoles
|2 NLM
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|a polydopamine
|2 NLM
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|a Polymers
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a Antimicrobial Peptides
|2 NLM
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1 |
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|a Liu, Yinghao
|e verfasserin
|4 aut
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1 |
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|a Zhang, Xue'e
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Mengzhen
|e verfasserin
|4 aut
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1 |
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|a Xi, Weihong
|e verfasserin
|4 aut
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| 700 |
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|a Wei, Junchao
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 40(2024), 47 vom: 26. Nov., Seite 25042-25050
|w (DE-627)NLM098181009
|x 1520-5827
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| 773 |
1 |
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|g volume:40
|g year:2024
|g number:47
|g day:26
|g month:11
|g pages:25042-25050
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|u http://dx.doi.org/10.1021/acs.langmuir.4c03206
|3 Volltext
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