Nucleus-Targeting Photosensitizers Enhance Neutrophil Extracellular Traps for Efficient Eradication of Multidrug-Resistant Bacterial Infections

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 50 vom: 09. Dez., Seite e2400304
1. Verfasser: Wang, Peng (VerfasserIn)
Weitere Verfasser: Bai, Qingqing, Liu, Xianglong, Zhao, Minyang, Chen, Lei, Hu, Fang, Ye, Jinzhou, Chen, Xinhan, Wang, Kang-Nan, Liu, Bin, Mao, Duo
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article antibacterial photodynamic therapy multidrug‐resistant bacterial infection neutrophil extracellular traps nucleus‐targeting photosensitizer Photosensitizing Agents Reactive Oxygen Species Anti-Bacterial Agents
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520 |a Neutrophil extracellular traps (NETs) are web-like complexes of DNA and proteins that are extruded by activated neutrophils and play critical roles as major components of the innate immune response against pathogen invasion. However, some microbes have developed strategies to evade NET attacks, leading to impaired immune defenses and persistent infections. In this study, an engineered neutrophil strategy for enhancing the antibacterial activity of NETs is developed. A nucleus-targeting photosensitizer (NCP) with strong reactive oxygen species production and a strong DNA-binding capacity is synthesized. NCP-loaded neutrophils are subsequently constructed via direct incubation of NCP with neutrophils, and the NCP is closely inserted into the nucleus DNA. Upon activation by bacteria-related toxins, NCP-coupled NETs can be released rapidly, actively trapping bacteria and providing a high local concentration of NCP around them. Both in vitro and in vivo results revealed that NCP-coupled NETs can effectively eradicate various multidrug-resistant bacteria and biofilms through photodynamic therapy, overcome bacterial immune evasion, and promote tissue recovery from severe wound infections. This design can significantly strengthen NET function, providing a non-antibiotic alternative platform for treating bacterial infectious diseases 
650 4 |a Journal Article 
650 4 |a antibacterial photodynamic therapy 
650 4 |a multidrug‐resistant bacterial infection 
650 4 |a neutrophil extracellular traps 
650 4 |a nucleus‐targeting photosensitizer 
650 7 |a Photosensitizing Agents  |2 NLM 
650 7 |a Reactive Oxygen Species  |2 NLM 
650 7 |a Anti-Bacterial Agents  |2 NLM 
700 1 |a Bai, Qingqing  |e verfasserin  |4 aut 
700 1 |a Liu, Xianglong  |e verfasserin  |4 aut 
700 1 |a Zhao, Minyang  |e verfasserin  |4 aut 
700 1 |a Chen, Lei  |e verfasserin  |4 aut 
700 1 |a Hu, Fang  |e verfasserin  |4 aut 
700 1 |a Ye, Jinzhou  |e verfasserin  |4 aut 
700 1 |a Chen, Xinhan  |e verfasserin  |4 aut 
700 1 |a Wang, Kang-Nan  |e verfasserin  |4 aut 
700 1 |a Liu, Bin  |e verfasserin  |4 aut 
700 1 |a Mao, Duo  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 36(2024), 50 vom: 09. Dez., Seite e2400304  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:36  |g year:2024  |g number:50  |g day:09  |g month:12  |g pages:e2400304 
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