Albumin-Chaperoned Deep-NIR Triarylmethane Dyes for High-Contrast In Vivo Imaging and Photothermal Therapy

Albumin-Chaperoned Deep-NIR Triarylmethane Dyes for High-Contrast In Vivo Imaging and Photothermal Therapy

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 37(2025), 1 vom: 08. Jan., Seite e2411515
1. Verfasser: Zhang, Xiaodong (VerfasserIn)
Weitere Verfasser: Liu, Ming, Hu, Yingqi, Wang, Xueli, Wei, Ruwei, Yao, Cheng, Shi, Cunjian, Qiu, Yangting, Yang, Tao, Luo, Xiao, Chen, Jinquan, Sun, Wen, Chen, Huabing, Qian, Xuhong, Yang, Youjun
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2025
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article albumin‐chaperon fluorescence imaging near‐infrared photocoustic imaging photothermal therapy Serum Albumin, Bovine 27432CM55Q Fluorescent Dyes Methane OP0UW79H66
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520 |a Fluorophores absorbing/emitting in the deep near-infrared (deep NIR) spectral region, that is, 800 nm and beyond, hold great promise for in vivo bioimaging, diagnosis, and phototherapy due to deeper tissue penetration. The bottleneck is the lack of bright, stable, and readily synthesized deep NIR fluorophores. Here, it is reported that the albumin-chaperon strategy is a viable one-for-all strategy to address these difficulties. A focused library of deep-NIR absorbing dyes (EA5) is easily synthesized via a two-step cascade. They are neither very stable nor bright in phosphate buffer due to a propeller-type flexible scaffold. Through screening, EA5_c3 is found to exhibit a high affinity toward bovine serum albumin (BSA). Binding-associated structural rigidification resulted in a gigantic 26-fold fluorescence enhancement. The albumin chaperone also greatly improved the stability of EA5_c3 by shielding the bisbenzannulated triarylmethane core from nucleophilic or oxidative species. The resulting EA5_c3BSA exhibits high biocompatibility. It offered high-resolution vasculature, lymph systems, tumors, and other tissue imaging with its bright deep NIR emission. At the same time, it exhibits prominent potential in photoacoustic imaging and photothermal treatment of subcutaneous and orthotopic breast tumors. These findings provide insights into robust and high-performance fluorophores with deep NIR regions for theranostic against aggressive cancers 
650 4 |a Journal Article 
650 4 |a albumin‐chaperon 
650 4 |a fluorescence imaging 
650 4 |a near‐infrared 
650 4 |a photocoustic imaging 
650 4 |a photothermal therapy 
650 7 |a Serum Albumin, Bovine  |2 NLM 
650 7 |a 27432CM55Q  |2 NLM 
650 7 |a Fluorescent Dyes  |2 NLM 
650 7 |a Methane  |2 NLM 
650 7 |a OP0UW79H66  |2 NLM 
700 1 |a Liu, Ming  |e verfasserin  |4 aut 
700 1 |a Hu, Yingqi  |e verfasserin  |4 aut 
700 1 |a Wang, Xueli  |e verfasserin  |4 aut 
700 1 |a Wei, Ruwei  |e verfasserin  |4 aut 
700 1 |a Yao, Cheng  |e verfasserin  |4 aut 
700 1 |a Shi, Cunjian  |e verfasserin  |4 aut 
700 1 |a Qiu, Yangting  |e verfasserin  |4 aut 
700 1 |a Yang, Tao  |e verfasserin  |4 aut 
700 1 |a Luo, Xiao  |e verfasserin  |4 aut 
700 1 |a Chen, Jinquan  |e verfasserin  |4 aut 
700 1 |a Sun, Wen  |e verfasserin  |4 aut 
700 1 |a Chen, Huabing  |e verfasserin  |4 aut 
700 1 |a Qian, Xuhong  |e verfasserin  |4 aut 
700 1 |a Yang, Youjun  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 37(2025), 1 vom: 08. Jan., Seite e2411515  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnas 
773 1 8 |g volume:37  |g year:2025  |g number:1  |g day:08  |g month:01  |g pages:e2411515 
856 4 0 |u http://dx.doi.org/10.1002/adma.202411515  |3 Volltext 
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