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241105s2025 xx |||||o 00| ||eng c |
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|a 10.1111/nph.20224
|2 doi
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|a pubmed25n1265.xml
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|a (DE-627)NLM379838311
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|a (NLM)39497276
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Liu, Cuixia
|e verfasserin
|4 aut
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| 245 |
1 |
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|a The Arabidopsis E3 ubiquitin ligase DOA10A promotes localization of abscisic acid (ABA) receptors to the membrane through mono-ubiquitination in ABA signaling
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|c 2025
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 05.12.2024
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|a Date Revised 05.12.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a © 2024 The Author(s). New Phytologist © 2024 New Phytologist Foundation.
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|a The endoplasmic reticulum-associated degradation (ERAD) system eliminates misfolded and short-lived proteins to maintain physiological homeostasis in the cell. We have previously reported that ERAD is involved in salt tolerance in Arabidopsis. Given the central role of the phytohormone abscisic acid (ABA) in plant stress responses, we sought to identify potential intersections between the ABA and the ERAD pathways in plant stress response. By screening for the ABA response of a wide array of ERAD mutants, we isolated a gain-of-function mutant, doa10a-1, which conferred ABA hypersensitivity to seedlings. Genetic and biochemical assays showed that DOA10A is a functional E3 ubiquitin ligase which, by acting in concert with specific E2 enzymes, mediates mono-ubiquitination of the ABA receptor, followed by their relocalization to the plasma membrane. This in turn leads to enhanced ABA perception. In summary, we report here the identification of a novel RING-type E3 ligase, DOA10A, which regulates ABA perception by affecting the localization and the activity of ABA receptors through their mono-ubiquitination
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|a Journal Article
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|a ABA signaling
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|a Arabidopsis
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|a DOA10A
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|a E3 ubiquitin ligase
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|a ERAD
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|a mono‐ubiquitination
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|a Abscisic Acid
|2 NLM
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| 650 |
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|a 72S9A8J5GW
|2 NLM
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| 650 |
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|a Ubiquitin-Protein Ligases
|2 NLM
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| 650 |
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|a EC 2.3.2.27
|2 NLM
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| 650 |
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|a Arabidopsis Proteins
|2 NLM
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| 650 |
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|a Receptors, Cell Surface
|2 NLM
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| 700 |
1 |
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|a Li, Qingliang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Zhengwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xia, Ran
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ding, Yanglin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Shuhua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Serino, Giovanna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Qi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Feifei
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 245(2025), 1 vom: 01. Jan., Seite 169-182
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnas
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| 773 |
1 |
8 |
|g volume:245
|g year:2025
|g number:1
|g day:01
|g month:01
|g pages:169-182
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| 856 |
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|u http://dx.doi.org/10.1111/nph.20224
|3 Volltext
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|a AR
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|d 245
|j 2025
|e 1
|b 01
|c 01
|h 169-182
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