|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM379246961 |
| 003 |
DE-627 |
| 005 |
20241029232532.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
241024s2024 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2024.110381
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1584.xml
|
| 035 |
|
|
|a (DE-627)NLM379246961
|
| 035 |
|
|
|a (NLM)39437979
|
| 035 |
|
|
|a (PII)S1521-6616(24)00490-X
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Liu, Ting-Yuan
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Characterization of primary Sjögren's syndrome in the Taiwan Han population through a genome-wide association study and polygenic risk score analysis
|
| 264 |
|
1 |
|c 2024
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Revised 28.10.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status Publisher
|
| 520 |
|
|
|a Copyright © 2024. Published by Elsevier Inc.
|
| 520 |
|
|
|a BACKGROUND: Sjögren's syndrome (SS) is an autoimmune disorder that primarily affects the exocrine glands, leading to dryness of mucous membranes and systemic manifestations. This study aimed to identify genetic markers associated with primary SS (pSS) in the Taiwan Han population through a hospital-based genome-wide association study (GWAS) and polygenic risk score (PRS) analysis, addressing the lack of genetic research
|
| 520 |
|
|
|a RESULTS: This study included 11,390 patients diagnosed with pSS and 113,900 controls. GWAS identified one known locus and eight novel loci. Known HLA alleles, including HLA-DRB1*15:01 and HLA-DQA1*03:01, were successfully replicated in a consistent effect direction. PRS analysis revealed that several autoimmune diseases share similar genetic backgrounds with pSS, including rheumatoid arthritis and systemic lupus erythematosus
|
| 520 |
|
|
|a CONCLUSION: This study represents the largest cohort to date on the genetics of pSS in the Taiwan Han population. Our findings provide valuable insights into the pathogenesis of pSS and emphasize the comorbidities associated with it as an autoimmune disease
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Gene polymorphism
|
| 650 |
|
4 |
|a Genome-wide association study (GWAS)
|
| 650 |
|
4 |
|a Human leukocyte antigen (HLA)
|
| 650 |
|
4 |
|a Phenome-wide association study (PheWAS)
|
| 650 |
|
4 |
|a Polygenic risk score (PRS)
|
| 650 |
|
4 |
|a Sjögren's syndrome
|
| 700 |
1 |
|
|a Lin, Min-Rou
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lu, Hsing-Fang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Yu-Chia
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lin, Hui-Ju
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chou, Wan-Hsuan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wei, Chun-Yu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Palupi, Poppy Diah
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liao, Chi-Chou
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chang, Yen-Ting
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chang, Wei-Chiao
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Tsai, Fuu-Jen
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 269(2024) vom: 20. Okt., Seite 110381
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:269
|g year:2024
|g day:20
|g month:10
|g pages:110381
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2024.110381
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 269
|j 2024
|b 20
|c 10
|h 110381
|