Responsive Magnetic Particle Imaging Tracer Overcoming "Always-On" Limitation, Eliminating Interference, and Ensuring Safety in Adaptive Therapy

Responsive Magnetic Particle Imaging Tracer : Overcoming "Always-On" Limitation, Eliminating Interference, and Ensuring Safety in Adaptive Therapy

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - (2024) vom: 15. Okt., Seite e2409117
1. Verfasser: Guan, Guoqiang (VerfasserIn)
Weitere Verfasser: Shi, Guangyuan, Liu, Huiyi, Xu, Juntao, Zhang, Qingpeng, Dong, Zhe, Lu, Chang, Wang, Youjuan, Lei, Lingling, Nan, Bin, Zhang, Cheng, Yue, Renye, Du, Yang, Tian, Jie, Song, Guosheng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article PdFe alloy adaptive therapy magnetic particle imaging responsive MPI tracer cancer imaging
Beschreibung
Zusammenfassung:© 2024 Wiley‐VCH GmbH.
Magnetic particle imaging (MPI) has emerged as a novel technology utilizing superparamagnetic nanoparticles as tracers, essential for disease diagnosis and treatment guidance in preclinical animal models. Unlike other modalities, MPI provides high sensitivity, deep tissue penetration, and no signal attenuation. However, existing MPI tracers suffer from "always-on" signals, which complicate organ-specific imaging and hinder accuracy. To overcome these challenges, we have developed a responsive MPI tracer using pH-responsive PdFe alloy particles coated with a gatekeeper polymer. This tracer exhibits pH-sensitive Fe release and modulation of the MPI signal, enabling selective imaging with a higher signal-to-noise ratio and intratumoral pH quantification. Notably, this responsive tracer facilitates subtraction-enhanced MPI imaging, effectively eliminating interference from liver uptake and expanding the scope of abdominal imaging. Additionally, the tracer employs a dual-function mechanism for adaptive cancer therapy, combining pH-switchable enzyme-like catalysis with dual-key co-activation of ROS generation, and Pd skeleton that scavenges free radicals to minimize Fe-related toxicity. This advancement promises to significantly expand MPI's applicability in diagnostics and therapeutic monitoring, marking a leap forward in imaging technology
Beschreibung:Date Revised 16.10.2024
published: Print-Electronic
Citation Status Publisher
ISSN:1521-4095
DOI:10.1002/adma.202409117