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241014s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202404514
|2 doi
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|a pubmed24n1631.xml
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|a DE-627
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|a eng
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|a Kim, Dong Wook
|e verfasserin
|4 aut
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|a Hierarchical Nanostructures as Acoustically Manipulatable Multifunctional Agents in Dynamic Fluid Flow
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 12.12.2024
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|a Date Revised 14.12.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
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|a Acoustic waves provide a biocompatible and deep-tissue-penetrating tool suitable for contactless manipulation in in vivo environments. Despite the prevalence of dynamic fluids within the body, previous studies have primarily focused on static fluids, and manipulatable agents in dynamic fluids are limited to gaseous core-shell particles. However, these gas-filled particles face challenges in fast-flow manipulation, complex setups, design versatility, and practical medical imaging, underscoring the need for effective alternatives. In this study, flower-like hierarchical nanostructures (HNS) into microparticles (MPs) are incorporated, and demonstrated that various materials fabricated as HNS-MPs exhibit effective and reproducible acoustic trapping within high-velocity fluid flows. Through simulations, it is validated that the HNS-MPs are drawn to the focal point by acoustic streaming and form a trap through secondary acoustic streaming at the tips of the nanosheets comprising the HNS-MPs. Furthermore, the wide range of materials and modification options for HNS, combined with their high surface area and biocompatibility, enable them to serve as acoustically manipulatable multimodal imaging contrast agents and microrobots. They can perform intravascular multi-trap maneuvering with real-time imaging, purification of wastewater flow, and highly-loaded drug delivery. Given the diverse HNS materials developed to date, this study extends their applications to acoustofluidic and biomedical fields
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|a Journal Article
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|a acoustic manipulation
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|a dynamic fluid
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|a hierarchical nanostructures
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|a medical imaging
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|a microrobots
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|a Contrast Media
|2 NLM
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| 650 |
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|a Biocompatible Materials
|2 NLM
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| 700 |
1 |
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|a Wrede, Paul
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Estrada, Hector
|e verfasserin
|4 aut
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| 700 |
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|a Yildiz, Erdost
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lazovic, Jelena
|e verfasserin
|4 aut
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| 700 |
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|a Bhargava, Aarushi
|e verfasserin
|4 aut
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|a Razansky, Daniel
|e verfasserin
|4 aut
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| 700 |
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|a Sitti, Metin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 50 vom: 01. Dez., Seite e2404514
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|g volume:36
|g year:2024
|g number:50
|g day:01
|g month:12
|g pages:e2404514
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|u http://dx.doi.org/10.1002/adma.202404514
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