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241010s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.4c03275
|2 doi
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|a eng
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|a Kao, Tzu-Yu
|e verfasserin
|4 aut
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|a Chelation-Induced Zwitterion-like Antifouling Behavior on Anionic Poly(3,4-ethylenedioxythiophene) Surfaces
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 22.10.2024
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|a Date Revised 26.10.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Antifouling properties are crucial for enhancing the longevity and functionality of biomedical implants, drug delivery systems, and biosensors. Zwitterionic polymers are renowned for their exceptional surface hydration and charge neutrality, which effectively resist biomolecular adsorption and protein attachment. We propose an innovative approach to develop zwitterion-like antifouling surfaces by chelating divalent cations with anionic poly(3,4-ethylenedioxythiophene) (PEDOT) films, specifically PEDOT-PO4 and PEDOT-COOH. The chelation behavior of these films was systematically evaluated using Na+, Mg2+, and Ca2+ ions. Divalent ions, particularly Ca2+ and Mg2+, exhibit a strong affinity for the anionic groups, leading to significant antifouling properties. These modified surfaces effectively repelled both negatively charged bovine serum albumin (BSA) and positively charged lysozyme (LYZ) proteins across various pH environments. This study offers valuable insights into the antifouling characteristics of charged surfaces, enhancing our understanding of how ion-mediated surface modifications influence protein adsorption and interactions
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|a Journal Article
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|a poly(3,4-ethylene dioxythiophene)
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|a Polymers
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|a Serum Albumin, Bovine
|2 NLM
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|a 27432CM55Q
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|a Bridged Bicyclo Compounds, Heterocyclic
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|a Chelating Agents
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|a Anions
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|a Muramidase
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|a EC 3.2.1.17
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|a Calcium
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|a SY7Q814VUP
|2 NLM
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1 |
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|a Gong, Ya-Chen
|e verfasserin
|4 aut
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1 |
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|a Huang, Cheng-Hsun
|e verfasserin
|4 aut
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| 700 |
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|a Wu, Yen-Ku
|e verfasserin
|4 aut
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| 700 |
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|a Luo, Shyh-Chyang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 40(2024), 42 vom: 22. Okt., Seite 22417-22423
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:40
|g year:2024
|g number:42
|g day:22
|g month:10
|g pages:22417-22423
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|u http://dx.doi.org/10.1021/acs.langmuir.4c03275
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