Interface/Dipole Polarized Antibiotics-Loaded Fe3O4/PB Nanoparticles for Non-Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 47 vom: 30. Nov., Seite e2410917
1. Verfasser:	Jin, Liguo (VerfasserIn)
Weitere Verfasser:	Liu, Hanpeng, Wang, Chaofeng, Mao, Congyang, Wu, Shuilin, Zhang, Yu, Li, Zhaoyang, Zhu, Shengli, Jiang, Hui, Cui, Zhenduo, Zheng, Yufeng, Liu, Xiangmei
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article Prussian blue nanoparticles antibacterial ferric oxide microwave therapy osteomyelitis Anti-Bacterial Agents Ferrocyanides Polylactic Acid-Polyglycolic Acid Copolymer 1SIA8062RS mehr... ferric ferrocyanide TLE294X33A Gentamicins Reactive Oxygen Species Ferric Compounds 1K09F3G675 Magnetite Nanoparticles Drug Carriers


LEADER	01000caa a22002652c 4500
001	NLM378316338
003	DE-627
005	20250306173527.0
007	cr uuu---uuuuu
008	240930s2024 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1002/adma.202410917 \|2 doi
028	5	2	\|a pubmed25n1260.xml
035			\|a (DE-627)NLM378316338
035			\|a (NLM)39344940
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
100	1		\|a Jin, Liguo \|e verfasserin \|4 aut
245	1	0	\|a Interface/Dipole Polarized Antibiotics-Loaded Fe3O4/PB Nanoparticles for Non-Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation
264		1	\|c 2024
336			\|a Text \|b txt \|2 rdacontent
337			\|a ƒaComputermedien \|b c \|2 rdamedia
338			\|a ƒa Online-Ressource \|b cr \|2 rdacarrier
500			\|a Date Completed 25.11.2024
500			\|a Date Revised 25.11.2024
500			\|a published: Print-Electronic
500			\|a Citation Status MEDLINE
520			\|a © 2024 Wiley‐VCH GmbH.
520			\|a Due to their poor light penetration, photothermal therapy and photodynamic therapy are ineffective in treating deep tissue infections, such as osteomyelitis caused by Staphylococcus aureus (S. aureus). Here, a microwave (MW)-responsive magnetic targeting composite system consisting of ferric oxide (Fe3O4)/Prussian blue (PB) nanoparticles, gentamicin (Gent), and biodegradable poly(lactic-co-glycolic acid) (PLGA) is reported. The PLGA/Fe3O4/PB/Gent complex is used in combination with MW thermal therapy (MTT), MW dynamic therapy (MDT), and chemotherapy (CT) to treat acute osteomyelitis infected with S. aureus-infected. The powerful antibacterial effect of the PLGA/Fe3O4/PB/Gent is determined by the synergistic effects of heat and reactive oxygen species (ROS) generation by the Fe3O4/PB nanoparticles under MW irradiation and the effective release of Gent at the infection site via magnetic targeting. The antibacterial mechanism of the PLGA/Fe3O4/PB/Gent under MW irradiation is analyzed using bacterial transcriptome RNA sequencing. The MW heat and ROS reduce the activity of the protein transporters on the bacterial membrane, along with the transport of various ions and the acceleration of phosphate metabolism, which can lead to increased permeability of the bacterial membrane, damage the ribosome and DNA, and accompany the internal protein efflux of the bacteria, thus effectively killing the bacteria
650		4	\|a Journal Article
650		4	\|a Prussian blue nanoparticles
650		4	\|a antibacterial
650		4	\|a ferric oxide
650		4	\|a microwave therapy
650		4	\|a osteomyelitis
650		7	\|a Anti-Bacterial Agents \|2 NLM
650		7	\|a Ferrocyanides \|2 NLM
650		7	\|a Polylactic Acid-Polyglycolic Acid Copolymer \|2 NLM
650		7	\|a 1SIA8062RS \|2 NLM
650		7	\|a ferric ferrocyanide \|2 NLM
650		7	\|a TLE294X33A \|2 NLM
650		7	\|a Gentamicins \|2 NLM
650		7	\|a Reactive Oxygen Species \|2 NLM
650		7	\|a Ferric Compounds \|2 NLM
650		7	\|a ferric oxide \|2 NLM
650		7	\|a 1K09F3G675 \|2 NLM
650		7	\|a Magnetite Nanoparticles \|2 NLM
650		7	\|a Drug Carriers \|2 NLM
700	1		\|a Liu, Hanpeng \|e verfasserin \|4 aut
700	1		\|a Wang, Chaofeng \|e verfasserin \|4 aut
700	1		\|a Mao, Congyang \|e verfasserin \|4 aut
700	1		\|a Wu, Shuilin \|e verfasserin \|4 aut
700	1		\|a Zhang, Yu \|e verfasserin \|4 aut
700	1		\|a Li, Zhaoyang \|e verfasserin \|4 aut
700	1		\|a Zhu, Shengli \|e verfasserin \|4 aut
700	1		\|a Jiang, Hui \|e verfasserin \|4 aut
700	1		\|a Cui, Zhenduo \|e verfasserin \|4 aut
700	1		\|a Zheng, Yufeng \|e verfasserin \|4 aut
700	1		\|a Liu, Xiangmei \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Advanced materials (Deerfield Beach, Fla.) \|d 1998 \|g 36(2024), 47 vom: 30. Nov., Seite e2410917 \|w (DE-627)NLM098206397 \|x 1521-4095 \|7 nnas
773	1	8	\|g volume:36 \|g year:2024 \|g number:47 \|g day:30 \|g month:11 \|g pages:e2410917
856	4	0	\|u http://dx.doi.org/10.1002/adma.202410917 \|3 Volltext
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_NLM
912			\|a GBV_ILN_350
951			\|a AR
952			\|d 36 \|j 2024 \|e 47 \|b 30 \|c 11 \|h e2410917