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240930s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202410142
|2 doi
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|a pubmed25n1260.xml
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|a (DE-627)NLM378316184
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|a (NLM)39344926
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Zhang, Wenguang
|e verfasserin
|4 aut
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|a Fiber Optic-Mediated Type I Photodynamic Therapy of Brain Glioblastoma Based on an Aggregation-Induced Emission Photosensitizer
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 25.11.2024
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|a Date Revised 25.11.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Glioblastoma (GBM) is one of the most lethal human malignancies. The current standard-of-care is highly invasive with strong toxic side effects, leading to poor prognosis and high mortality. As a safe and effective clinical approach, photodynamic therapy (PDT) has emerged as a suitable option for GBM. Nevertheless, its implementation is significantly impeded by the limits of light penetration depth and the firm reliance on oxygen. To overcome these challenges, herein, a promising strategy that harnesses a modified optical fiber and less oxygen-dependent Type I aggregation-induced emission (AIE) photosensitizer (PS) is developed for the first time to realize in vivo GBM treatments. The proposed AIE PS, namely TTTMN, characterized by a highly twisted molecular architecture and a bulky spacer, exhibits enhanced near-infrared emission and strong production of hydroxyl and superoxide radicals at the aggregated state, thus affording efficient fluorescence imaging-guided PDT once formulated into nanoparticles. The inhibition of orthotopic and subcutaneous GBM xenografts provides compelling evidence of the treatment efficacy of Type I PDT irradiated through a tumor-inserted optical fiber. These findings highlight the substantially improved therapeutic outcomes achieved through fiber optic-mediated Type I PDT, positioning it as a promising therapeutic modality for GBM
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|a Journal Article
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|a Type I photosensitizer
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4 |
|a aggregation‐induced emission
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|a brain glioblastoma
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|a optical fiber
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|a photodynamic theranostics
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|a Photosensitizing Agents
|2 NLM
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| 700 |
1 |
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|a Kang, Miaomiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pan, Yinzhen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Zhuorong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yibin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liao, Changrui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Gaixia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zhijun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Ben Zhong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Zhourui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Dong
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 47 vom: 30. Nov., Seite e2410142
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
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|g volume:36
|g year:2024
|g number:47
|g day:30
|g month:11
|g pages:e2410142
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202410142
|3 Volltext
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