Toward a Radically Simple Multi-Modal Nasal Spray for Preventing Respiratory Infections

Toward a Radically Simple Multi-Modal Nasal Spray for Preventing Respiratory Infections

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - (2024) vom: 24. Sept., Seite e2406348
1. Verfasser: Joseph, John (VerfasserIn)
Weitere Verfasser: Baby, Helna Mary, Quintero, Joselyn Rojas, Kenney, Devin, Mebratu, Yohannes A, Bhatia, Eshant, Shah, Purna, Swain, Kabir, Lee, Dongtak, Kaur, Shahdeep, Li, Xiang-Ling, Mwangi, John, Snapper, Olivia, Nair, Remya, Agus, Eli, Ranganathan, Sruthi, Kage, Julian, Gao, Jingjing, Luo, James N, Yu, Anthony, Park, Dongsung, Douam, Florian, Tesfaigzi, Yohannes, Karp, Jeffrey M, Joshi, Nitin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article antibacterial antiviral broad spectrum protection nasal prophylaxis nasal spray pathogen capture respiratory infections virus neutralization
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520 |a Nasal sprays for pre-exposure prophylaxis against respiratory infections show limited protection (20-70%), largely due to their single mechanism of action-either neutralizing pathogens or blocking their entry at the nasal lining, and a failure to maximize the capture of respiratory droplets, allowing them to potentially rebound and reach deeper airways. This report introduces the Pathogen Capture and Neutralizing Spray (PCANS), which utilizes a multi-modal approach to enhance efficacy. PCANS coats the nasal cavity, capturing large respiratory droplets from the air, and serving as a physical barrier against a broad spectrum of viruses and bacteria, while rapidly neutralizing them with over 99.99% effectiveness. The formulation consists of excipients identified from the FDA's Inactive Ingredient Database and Generally Recognized as Safe list to maximize efficacy for each step in the multi-modal approach. PCANS demonstrates nasal retention for up to 8 hours in mice. In a severe Influenza A mouse model, a single pre-exposure dose of PCANS leads to a >99.99% reduction in lung viral titer and ensures 100% survival, compared to 0% in the control group. PCANS suppresses pathological manifestations and offers protection for at least 4 hours. This data suggest PCANS as a promising daily-use prophylactic against respiratory infections 
650 4 |a Journal Article 
650 4 |a antibacterial 
650 4 |a antiviral 
650 4 |a broad spectrum protection 
650 4 |a nasal prophylaxis 
650 4 |a nasal spray 
650 4 |a pathogen capture 
650 4 |a respiratory infections 
650 4 |a virus neutralization 
700 1 |a Baby, Helna Mary  |e verfasserin  |4 aut 
700 1 |a Quintero, Joselyn Rojas  |e verfasserin  |4 aut 
700 1 |a Kenney, Devin  |e verfasserin  |4 aut 
700 1 |a Mebratu, Yohannes A  |e verfasserin  |4 aut 
700 1 |a Bhatia, Eshant  |e verfasserin  |4 aut 
700 1 |a Shah, Purna  |e verfasserin  |4 aut 
700 1 |a Swain, Kabir  |e verfasserin  |4 aut 
700 1 |a Lee, Dongtak  |e verfasserin  |4 aut 
700 1 |a Kaur, Shahdeep  |e verfasserin  |4 aut 
700 1 |a Li, Xiang-Ling  |e verfasserin  |4 aut 
700 1 |a Mwangi, John  |e verfasserin  |4 aut 
700 1 |a Snapper, Olivia  |e verfasserin  |4 aut 
700 1 |a Nair, Remya  |e verfasserin  |4 aut 
700 1 |a Agus, Eli  |e verfasserin  |4 aut 
700 1 |a Ranganathan, Sruthi  |e verfasserin  |4 aut 
700 1 |a Kage, Julian  |e verfasserin  |4 aut 
700 1 |a Gao, Jingjing  |e verfasserin  |4 aut 
700 1 |a Luo, James N  |e verfasserin  |4 aut 
700 1 |a Yu, Anthony  |e verfasserin  |4 aut 
700 1 |a Park, Dongsung  |e verfasserin  |4 aut 
700 1 |a Douam, Florian  |e verfasserin  |4 aut 
700 1 |a Tesfaigzi, Yohannes  |e verfasserin  |4 aut 
700 1 |a Karp, Jeffrey M  |e verfasserin  |4 aut 
700 1 |a Joshi, Nitin  |e verfasserin  |4 aut 
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