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20241214232121.0 |
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240923s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202408329
|2 doi
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|a pubmed24n1631.xml
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|a (DE-627)NLM377952494
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|a (NLM)39308296
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Jeon, Seunggyu
|e verfasserin
|4 aut
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| 245 |
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|a High-Efficiency, Prevascularization-Free Macroencapsulation System for Subcutaneous Transplantation of Pancreatic Islets for Enhanced Diabetes Treatment
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 12.12.2024
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|a Date Revised 14.12.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
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|a Pancreatic islet macroencapsulation systems for subcutaneous transplantation have garnered significant attention as a therapy for Type I diabetes due to their minimal invasiveness and low complication rates. However, the low vascular density of subcutaneous tissue threatens the long-term survival of islets. To address this issue, prevascularized systems are introduced but various challenges remain, including system complexity and vascular-cell immunogenicity. Here, a novel prevasculature-free macroencapsulation system designed as a multilayer sheet, which ensures sufficient mass transport even in regions with sparse vasculature, is presented. Islets are localized in top/bottom micro-shell layers (≈300 µm thick) to maximize proximity to the surrounding host vasculature. These sheets, fabricated via bioprinting using rat islets and alginate-based bio-ink, double islet viability and optimize islet density, improving insulin secretion function by 240%. The subcutaneous transplantation of small islet masses (≈250 islet equivalent) into diabetic nude mice enable rapid (<1 day) recovery of blood glucose, which remain stable for >120 days. Additionally, antifibrotic drug-loaded multilayer sheets facilitate blood glucose regulation by rat islets at the subcutaneous sites of diabetic immunocompetent mice for >35 days. Thus, this macroencapsulation system can advance the treatment of Type I diabetes and is also effective for islet xenotransplantation in subcutaneous tissue
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|a Journal Article
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|a bioprinting
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| 650 |
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4 |
|a macroencapsulation system
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| 650 |
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|a pancreatic islet transplantation
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| 650 |
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4 |
|a subcutaneous transplantation
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| 650 |
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4 |
|a type I diabetes
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| 650 |
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|a Alginates
|2 NLM
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| 650 |
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|a Blood Glucose
|2 NLM
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| 650 |
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7 |
|a Insulin
|2 NLM
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| 700 |
1 |
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|a Heo, Jun-Ho
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Myung, Noehyun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shin, Ji Yeong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Min Kyeong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kang, Hyun-Wook
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 50 vom: 01. Dez., Seite e2408329
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:36
|g year:2024
|g number:50
|g day:01
|g month:12
|g pages:e2408329
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|u http://dx.doi.org/10.1002/adma.202408329
|3 Volltext
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