Single Atom Engineered Antibiotics Overcome Bacterial Resistance

Détails bibliographiques
Publié dans:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 50 vom: 23. Dez., Seite e2410652
Auteur principal:	Panáček, David (Auteur)
Autres auteurs:	Belza, Jan, Hochvaldová, Lucie, Baďura, Zdeněk, Zoppellaro, Giorgio, Šrejber, Martin, Malina, Tomáš, Šedajová, Veronika, Paloncýová, Markéta, Langer, Rostislav, Zdražil, Lukáš, Zeng, Jianrong, Li, Lina, Zhao, En, Chen, Zupeng, Xiong, Zhiqiang, Li, Ruibin, Panáček, Aleš, Večeřová, Renata, Kučová, Pavla, Kolář, Milan, Otyepka, Michal, Bakandritsos, Aristides, Zbořil, Radek
Format:	Article en ligne
Langue:	English
Publié:	2024
Accès à la collection:	Advanced materials (Deerfield Beach, Fla.)
Sujets:	Journal Article antibiotic cytocompatibility manganese multi‐drug resistance single‐atom Anti-Bacterial Agents Manganese 42Z2K6ZL8P Graphite plus... 7782-42-5 Nitrogen N762921K75

Description
Résumé:	© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH. The outbreak of antibiotic-resistant bacteria, or "superbugs", poses a global public health hazard due to their resilience against the most effective last-line antibiotics. Identifying potent antibacterial agents capable of evading bacterial resistance mechanisms represents the ultimate defense strategy. This study shows that -the otherwise essential micronutrient- manganese turns into a broad-spectrum potent antibiotic when coordinated with a carboxylated nitrogen-doped graphene. This antibiotic material (termed NGA-Mn) not only inhibits the growth of a wide spectrum of multidrug-resistant bacteria but also heals wounds infected by bacteria in vivo and, most importantly, effectively evades bacterial resistance development. NGA-Mn exhibits up to 25-fold higher cytocompatibility to human cells than its minimum bacterial inhibitory concentration, demonstrating its potential as a next-generation antibacterial agent. Experimental findings suggest that NGA-Mn acts on the outer side of the bacterial cell membrane via a multimolecular collective binding, blocking vital functions in both Gram-positive and Gram-negative bacteria. The results underscore the potential of single-atom engineering toward potent antibiotics, offering simultaneously a long-sought solution for evading drug resistance development while being cytocompatible to human cells
Description:	Date Completed 12.12.2024 Date Revised 14.12.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202410652