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240912s2024 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/adma.202314232
|2 doi
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|a pubmed24n1531.xml
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Xiao, Yu
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a In Vivo Interactions of Nucleic Acid Nanostructures With Cells
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| 264 |
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1 |
|c 2024
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| 336 |
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|a Text
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|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Revised 12.09.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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| 520 |
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|a © 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
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|a Nucleic acid nanostructures, derived from the assembly of nucleic acid building blocks (e.g., plasmids and oligonucleotides), are important intracellular carriers of therapeutic cargoes widely utilized in preclinical nanomedicine applications, yet their clinical translation remains scarce. In the era of "translational nucleic acid nanotechnology", a deeper mechanistic understanding of the interactions of nucleic acid nanostructures with cells in vivo will guide the development of more efficacious nanomedicines. This review showcases the recent progress in dissecting the in vivo interactions of four key types of nucleic acid nanostructures (i.e., tile-based, origami, spherical nucleic acid, and nucleic acid nanogel) with cells in rodents over the past five years. Emphasis lies on the cellular-level distribution of nucleic acid nanostructures in various organs and tissues and the cellular responses induced by their cellular entry. Next, in the spirit of preclinical translation, this review features the latest interactions of nucleic acid nanostructures with cells in large animals and humans. Finally, the review offers directions for studying the interactions of nucleic acid nanostructures with cells from both materials and biology perspectives and concludes with some regulatory updates
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|a Journal Article
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|a Review
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4 |
|a bio‐nano interaction
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| 650 |
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4 |
|a gene delivery
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| 650 |
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4 |
|a nanomedicines
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| 650 |
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4 |
|a nucleic acid nanotechnology
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| 650 |
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4 |
|a preclinical research
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| 700 |
1 |
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|a Liang, Zhihui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shyngys, Moldir
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Baekova, Aiana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheung, Suen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Muljadi, Mathias Billy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bai, Qianqian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Lula
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Choi, Chung Hang Jonathan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g (2024) vom: 12. Sept., Seite e2314232
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