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240906s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110353
|2 doi
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|a pubmed25n1256.xml
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|a (DE-627)NLM377241822
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|a (NLM)39237077
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|a (PII)S1521-6616(24)00462-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Yuan, Mo
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The anti-mCRP199-206 antibodies aggravate tubulointerstitial lesions in lupus nephritis
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|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 04.11.2024
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|a Date Revised 04.11.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024. Published by Elsevier Inc.
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|a Tubulointerstitial lesions could also be prominent in lupus nephritis, and the pathogenesis of tubulointerstitial lesions may be different from glomerular lesions. Previous studies have showed that plasma antibodies against modified /monomeric C-reactive protein (mCRP) are associated with renal tubulointerstitial lesions in patients with lupus nephritis, and amino acid (aa) 199-206 was one of the major epitopes of mCRP. However, the role of anti-mCRP199-206 antibodies in the pathogenesis of tubulointerstitial lesions in lupus nephritis is unknown. A total of 95 patients with renal biopsy-proven lupus nephritis were enrolled in this study. Plasma levels of anti-mCRP199-206 antibodies were screened by enzyme-linked immunosorbent assay (ELISA). A lupus prone mouse model was immunized using peptides mCRP199-206 to explore the potential role of anti-mCRP199-206 antibodies in tubulointerstitial lesions. The mechanism of anti-mCRP199-206 antibodies damage to renal tubular epithelial cells was investigated in vitro. Plasma antibodies against mCRP199-206 were associated with renal tubulointerstitial lesions and prognosis in patients with lupus nephritis. Immunization with peptides mCRP199-206 in lupus prone mice could aggravate tubulointerstitial lesions and drive tubulointerstitial inflammation and fibrosis. Anti-mCRP 199-206 antibodies could activate the TGF-β1/Smad3 signal pathway and induce tubular damage by binding with CRP. Circulating antibodies against mCRP199-206 could be a biomarker to reveal tubulointerstitial lesion, and participate in the pathogenesis of tubulointerstitial lesions, which might provide a potential therapeutic target for lupus nephritis
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|a Journal Article
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|a Anti-modified /monomeric C-reactive protein antibody
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4 |
|a C-reactive protein
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4 |
|a Lupus nephritis
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| 650 |
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4 |
|a Systemic lupus erythematosus
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| 650 |
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4 |
|a Tubulointerstitial lesions
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| 650 |
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7 |
|a C-Reactive Protein
|2 NLM
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| 650 |
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7 |
|a 9007-41-4
|2 NLM
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a Transforming Growth Factor beta1
|2 NLM
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| 700 |
1 |
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|a Zhao, Ming-Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tan, Ying
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 268(2024) vom: 15. Nov., Seite 110353
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
8 |
|g volume:268
|g year:2024
|g day:15
|g month:11
|g pages:110353
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2024.110353
|3 Volltext
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|a SYSFLAG_A
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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|a AR
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|d 268
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|h 110353
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