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240904s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.4c02563
|2 doi
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|a pubmed24n1536.xml
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|a (DE-627)NLM377135836
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|a (NLM)39226467
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|a DE-627
|b ger
|c DE-627
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|a eng
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| 100 |
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|a Chen, Xue
|e verfasserin
|4 aut
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|a Synthesis of a Zn(II)-2-aminoimidazole Framework as an Efficient Carbonic Anhydrase Mimic
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 17.09.2024
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|a Date Revised 17.09.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Carbonic anhydrase (CA) plays a crucial role in the CO2 capture processes by catalyzing the hydration of CO2. In this study, we synthesized a bioinspired carbonic anhydrase Zn-MOF (metal-organic framework) incorporating 2-aminoimidazole and Zn2+ as initial constituents. The synthesized Zn-MOF exhibited promising potential for efficiently catalyzing the CO2 hydration. Structural analyses such as SEM, XRD, and BET confirmed that the Zn-MOF crystal consisted of stacked grains with an average size of approximately 36 nm, forming a micron-sized spherical structure. Functionally, Zn-MOF exhibited effective catalytic activity toward both CO2 hydration and ester hydrolysis. The introduction of amino groups significantly enhanced the esterase activity of Zn-MOF to 0.28 U/mg at ambient temperature, which was twice that of ZIF-8. Furthermore, the introduction of amino groups resulted in remarkable hydrothermal stability, with the esterase activity reaching 0.72 U/mg after undergoing hydrothermal treatment at 80 °C for 12 h. Additionally, Zn-MOF exhibited enhanced capability in CO2 hydration at a pH value exceeding 8.5. After six repeated uses, ZIF-8 and Zn-MOF retained approximately 68 and 65% of their initial enzyme activity, respectively, underscoring the potential practical applicability of Zn-MOF in industrial CO2 capture processes. This work showcases the development of a novel Zn-MOF crystal as an efficient CA mimic, effectively emulating the active sites of natural CA using 2-aminoimidazole as a coordinating ligand for Zn2+ coordination. These findings not only advance the field of innovative enzyme mimics but also pave the way for further exploration of industrial CO2 capture catalysts
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|a Journal Article
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|a Carbonic Anhydrases
|2 NLM
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|a EC 4.2.1.1
|2 NLM
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|a Imidazoles
|2 NLM
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|a Zinc
|2 NLM
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|a J41CSQ7QDS
|2 NLM
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|a Carbon Dioxide
|2 NLM
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|a 142M471B3J
|2 NLM
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|a Metal-Organic Frameworks
|2 NLM
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|a Esterases
|2 NLM
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|a EC 3.1.-
|2 NLM
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|a Xiang, Yong
|e verfasserin
|4 aut
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|a Zhang, Xiaojing
|e verfasserin
|4 aut
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|a Li, Guanlin
|e verfasserin
|4 aut
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|a Ai, Sihan
|e verfasserin
|4 aut
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|a Yu, Daoyong
|e verfasserin
|4 aut
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|a Ge, Baosheng
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 40(2024), 37 vom: 17. Sept., Seite 19775-19786
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:40
|g year:2024
|g number:37
|g day:17
|g month:09
|g pages:19775-19786
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|u http://dx.doi.org/10.1021/acs.langmuir.4c02563
|3 Volltext
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|d 40
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|h 19775-19786
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