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240902s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110352
|2 doi
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|a pubmed25n1256.xml
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|a eng
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| 100 |
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|a García-Patiño, M G
|e verfasserin
|4 aut
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|a IL-17 in skin infections and homeostasis
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|c 2024
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|a Text
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|a ƒaComputermedien
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|a Date Completed 14.09.2024
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|a Date Revised 23.09.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Interleukin (IL) 17 is a proinflammatory cytokine belonging to a structurally related group of cytokines known as the IL-17 family. It has been profoundly studied for its contribution to the pathology of autoimmune diseases. However, it also plays an important role in homeostasis and the defense against extracellular bacteria and fungi. IL-17 is important for epithelial barriers, including the skin, where some of its cellular targets reside. Most of the research work on IL-17 has focused on its effects in the skin within the context of autoimmune diseases or sterile inflammation, despite also having impact on other skin conditions. In recent years, studies on the role of IL-17 in the defense against skin pathogens and in the maintenance of skin homeostasis mediated by the microbiota have grown in importance. Here we review and discuss the cumulative evidence regarding the main contribution of IL-17 in the maintenance of skin integrity as well as its protective or pathogenic effects during some skin infections
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|a Journal Article
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|a Review
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|a Homeostasis
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|a IL-17
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|a Infection
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|a Skin
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| 650 |
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|a Interleukin-17
|2 NLM
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| 700 |
1 |
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|a Marcial-Medina, M C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ruiz-Medina, B E
|e verfasserin
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1 |
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|a Licona-Limón, P
|e verfasserin
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 267(2024) vom: 15. Okt., Seite 110352
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|x 1521-7035
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|g volume:267
|g year:2024
|g day:15
|g month:10
|g pages:110352
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|u http://dx.doi.org/10.1016/j.clim.2024.110352
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