|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM377039012 |
| 003 |
DE-627 |
| 005 |
20240925232726.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
240902s2024 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2024.110351
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1548.xml
|
| 035 |
|
|
|a (DE-627)NLM377039012
|
| 035 |
|
|
|a (NLM)39216780
|
| 035 |
|
|
|a (PII)S1521-6616(24)00460-1
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Al-Rashed, Fatema
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages
|
| 264 |
|
1 |
|c 2024
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 14.09.2024
|
| 500 |
|
|
|a Date Revised 24.09.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Atherosclerosis is a cardiovascular disease caused by cholesterol-laden arterial plaques. This study evaluated the correlation between interleukin-6 (IL-6), its receptors (IL6R/CD126), and glycoprotein 130 (gp130) alongside atherosclerosis biomarkers in a cohort of 142 subjects, equally divided between lean and obese individuals. Subsequent analyses used THP-1-derived macrophages to assess the biochemical impact of inhibiting IL-6 receptors. IL-6 secretion increased with atherosclerosis in obese subjects, while IL6R/CD126 and gp130 on monocytes decreased. Pharmacological gp130 inhibition altered lipid metabolism, increasing LDLR gene expression and cholesterol synthesis via SREBF2 and mevalonate kinase, along with HMG-CoA reductase at protein levels. gp130-deficient cells produced more cholesterol and had lower ABCA1 levels, suggesting hindered cholesterol efflux. Filipin III staining confirmed cholesterol retention in gp130-inhibited cells. Ex-vivo investigation on lean PBMCs further defined the impact of gp130 inhibition on the reduction of cholesterol efflux. Our results indicates gp130 is crucial for macrophage reverse cholesterol transport and may be a target for atherosclerosis treatments
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a ABCA1
|
| 650 |
|
4 |
|a Atherosclerosis
|
| 650 |
|
4 |
|a Cholesterol
|
| 650 |
|
4 |
|a Cytokines
|
| 650 |
|
4 |
|a IL-6
|
| 650 |
|
4 |
|a LDLR
|
| 650 |
|
4 |
|a Monocytes
|
| 650 |
|
4 |
|a gp130
|
| 650 |
|
7 |
|a Cholesterol
|2 NLM
|
| 650 |
|
7 |
|a 97C5T2UQ7J
|2 NLM
|
| 650 |
|
7 |
|a Cytokine Receptor gp130
|2 NLM
|
| 650 |
|
7 |
|a 133483-10-0
|2 NLM
|
| 650 |
|
7 |
|a IL6R protein, human
|2 NLM
|
| 650 |
|
7 |
|a Interleukin-6
|2 NLM
|
| 650 |
|
7 |
|a Receptors, Interleukin-6
|2 NLM
|
| 650 |
|
7 |
|a Receptors, LDL
|2 NLM
|
| 700 |
1 |
|
|a AlSaeed, Halemah
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Almansour, Nourah
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Al-Mulla, Fahd
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hannun, Yusuf A
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ahmad, Rasheed
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 267(2024) vom: 30. Sept., Seite 110351
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:267
|g year:2024
|g day:30
|g month:09
|g pages:110351
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2024.110351
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 267
|j 2024
|b 30
|c 09
|h 110351
|