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|a 10.1021/acs.langmuir.4c01654
|2 doi
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|a pubmed24n1536.xml
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|a eng
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| 100 |
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|a Bregnhøj, Mikkel
|e verfasserin
|4 aut
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| 245 |
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|a De Novo Design and Characterization of Amphiphilic Peptides with Basic Side Chains for Tailored Interfacial Chemistries
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 17.09.2024
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|a Date Revised 17.09.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Lysine-leucine (LK) peptides have been used as model systems and platforms for 2D material design for decades. LK peptides are amphiphilic sequences designed to bind and fold at hydrophobic surfaces through hydrophobic leucine side chains and hydrophilic lysine side chains extending into the aqueous subphase. The hydrophobic periodicity of the sequence dictates the secondary structure at the interface. This robust design makes them ideal candidates for controlling interfacial chemistry. This study presents the de novo design and characterization of two novel peptides: LRα14 and LHα14, which substitute lysine with arginine and histidine, respectively, in the helical LKα14 sequence. This modification is intended to expand the LK peptide platform to a new basic interfacial chemistry. We explore the stability of the new LRα14 and LHα14 designs with respect to changes in pH and salt concentration in bulk solution and at the interface using circular dichroism (UV-CD) and vibrational sum-frequency generation spectroscopy, respectively. Notably, the structural stability of the peptides remains unaffected across a wide range of pH and ionic strength values. At the same time, the variation of side-chain chemistry leads to a wide spectrum of interfacial water structures. By extension of the LK platform to include arginine and histidine, this study broadens the toolbox for designing tailored interfacial chemistries with applications in material and biomedical sciences
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|a Journal Article
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|a Peptides
|2 NLM
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|a Lysine
|2 NLM
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|a K3Z4F929H6
|2 NLM
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|a Leucine
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|a GMW67QNF9C
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|a Surface-Active Agents
|2 NLM
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|a Golbek, Thaddeus W
|e verfasserin
|4 aut
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|a Madzharova, Fani
|e verfasserin
|4 aut
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| 700 |
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|a Weidner, Tobias
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 40(2024), 37 vom: 17. Sept., Seite 19404-19411
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:40
|g year:2024
|g number:37
|g day:17
|g month:09
|g pages:19404-19411
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|u http://dx.doi.org/10.1021/acs.langmuir.4c01654
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