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240822s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202409362
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|a eng
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1 |
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|a Cao, Yang
|e verfasserin
|4 aut
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|a Affinity-Controlled Partitioning of Biomolecules at Aqueous Interfaces and Their Bioanalytic Applications
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|c 2024
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Revised 22.08.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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| 520 |
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|a © 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
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|a All-aqueous phase separation systems play essential roles in bioanalytical and biochemical applications. Compared to conventional oil and organic solvent-based systems, these systems are characterized by their rich bulk and interfacial properties, offering superior biocompatibility. In particular, phase separation in all-aqueous systems facilitates the creation of compartments with specific physicochemical properties, and therefore largely enhances the accessibility of the systems. In addition, the all-aqueous compartments have diverse affinities, with an important property known as partitioning, which can concentrate (bio)molecules toward distinct immiscible phases. This partitioning affinity imparts all-aqueous interfaces with selective permeability, enabling the controlled enrichment of target (bio)molecules. This review introduces the basic principles and applications of partitioning-induced interfacial phenomena in a typical all-aqueous system, namely aqueous two-phase systems (ATPSs); these applications include interfacial chemical reactions, bioprinting, and assembly, as well as bio-sensing and detection. The primary challenges associated with designing all-aqueous phase separation systems and several future directions are also discussed, such as the stabilization of aqueous interfaces, the handling of low-volume samples, and exploration of suitable ATPSs compositions with the efficient protocol
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|a Journal Article
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|a Review
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|a ATPSs
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4 |
|a all‐aqueous phase separation systems
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| 650 |
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|a bioanalytical applications
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| 650 |
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4 |
|a interfacial phenomena
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| 700 |
1 |
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|a Chao, Youchuang
|e verfasserin
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| 700 |
1 |
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|a Shum, Ho Cheung
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g (2024) vom: 22. Aug., Seite e2409362
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|u http://dx.doi.org/10.1002/adma.202409362
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