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|a 10.1002/adma.202409362
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|a eng
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| 100 |
1 |
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|a Cao, Yang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Affinity-Controlled Partitioning of Biomolecules at Aqueous Interfaces and Their Bioanalytic Applications
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|c 2024
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|a Text
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|a ƒaComputermedien
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|a Date Completed 01.11.2024
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|a Date Revised 01.11.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
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|a All-aqueous phase separation systems play essential roles in bioanalytical and biochemical applications. Compared to conventional oil and organic solvent-based systems, these systems are characterized by their rich bulk and interfacial properties, offering superior biocompatibility. In particular, phase separation in all-aqueous systems facilitates the creation of compartments with specific physicochemical properties, and therefore largely enhances the accessibility of the systems. In addition, the all-aqueous compartments have diverse affinities, with an important property known as partitioning, which can concentrate (bio)molecules toward distinct immiscible phases. This partitioning affinity imparts all-aqueous interfaces with selective permeability, enabling the controlled enrichment of target (bio)molecules. This review introduces the basic principles and applications of partitioning-induced interfacial phenomena in a typical all-aqueous system, namely aqueous two-phase systems (ATPSs); these applications include interfacial chemical reactions, bioprinting, and assembly, as well as bio-sensing and detection. The primary challenges associated with designing all-aqueous phase separation systems and several future directions are also discussed, such as the stabilization of aqueous interfaces, the handling of low-volume samples, and exploration of suitable ATPSs compositions with the efficient protocol
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|a Journal Article
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|a Review
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|a ATPSs
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|a all‐aqueous phase separation systems
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|a bioanalytical applications
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| 650 |
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|a interfacial phenomena
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|a Water
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|a Shum, Ho Cheung
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 36(2024), 44 vom: 01. Nov., Seite e2409362
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