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20240819232519.0 |
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240819s2024 xx |||||o 00| ||eng c |
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|a 10.1111/nph.20063
|2 doi
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|a pubmed24n1506.xml
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|a (NLM)39155769
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Kusch, Stefan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a A fungal plant pathogen overcomes mlo-mediated broad-spectrum disease resistance by rapid gene loss
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| 264 |
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|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Revised 19.08.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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| 520 |
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|a © 2024 The Author(s). New Phytologist © 2024 New Phytologist Foundation.
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|a Hosts and pathogens typically engage in a coevolutionary arms race. This also applies to phytopathogenic powdery mildew fungi, which can rapidly overcome plant resistance and perform host jumps. Using experimental evolution, we show that the powdery mildew pathogen Blumeria hordei is capable of breaking the agriculturally important broad-spectrum resistance conditioned by barley loss-of-function mlo mutants. Partial mlo virulence of evolved B. hordei isolates is correlated with a distinctive pattern of adaptive mutations, including small-sized (c. 8-40 kb) deletions, of which one is linked to the de novo insertion of a transposable element. Occurrence of the mutations is associated with a transcriptional induction of effector protein-encoding genes that is absent in mlo-avirulent isolates on mlo mutant plants. The detected mutational spectrum comprises the same loci in at least two independently isolated mlo-virulent isolates, indicating convergent multigenic evolution. The mutational events emerged in part early (within the first five asexual generations) during experimental evolution, likely generating a founder population in which incipient mlo virulence was later stabilized by additional events. This work highlights the rapid dynamic genome evolution of an obligate biotrophic plant pathogen with a transposon-enriched genome
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| 650 |
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|a Journal Article
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| 650 |
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4 |
|a adaptation
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| 650 |
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4 |
|a experimental evolution
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| 650 |
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4 |
|a genome
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| 650 |
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4 |
|a plant immunity
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| 650 |
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4 |
|a powdery mildew
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| 650 |
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4 |
|a rapid evolution
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| 700 |
1 |
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|a Frantzeskakis, Lamprinos
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lassen, Birthe D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kümmel, Florian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pesch, Lina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Barsoum, Mirna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Walden, Kim D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Panstruga, Ralph
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g (2024) vom: 19. Aug.
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g year:2024
|g day:19
|g month:08
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| 856 |
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|u http://dx.doi.org/10.1111/nph.20063
|3 Volltext
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