Self-Growing Hydrogel Bioadhesives for Chronic Wound Management

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 41 vom: 16. Okt., Seite e2408538
1. Verfasser:	Zheng, Ziman (VerfasserIn)
Weitere Verfasser:	Chen, Xingmei, Wang, Yafei, Wen, Ping, Duan, Qingfang, Zhang, Pei, Shan, Liangjie, Ni, Zhipeng, Feng, Yinghui, Xue, Yu, Li, Xing, Zhang, Lin, Liu, Ji
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article chronic wound management hydrogel bioadhesive mechanical modulation mechanical strengthening self‐growing Hydrogels Tissue Adhesives

Beschreibung
Zusammenfassung:	© 2024 Wiley‐VCH GmbH. Hydrogel bioadhesives have emerged as a promising alternative to wound dressings for chronic wound management. However, many existing bioadhesives do not meet the functional requirements for efficient wound management through dynamically mechanical modulation, due to the reduced wound contractibility, frequent wound recurrence, incapability to actively adapt to external microenvironment variation, especially for those gradually-expanded chronic wounds. Here, a self-growing hydrogel bioadhesive (sGHB) patch that exhibits instant adhesion to biological tissues but also a gradual increase in mechanical strength and interfacial adhesive strength within a 120-h application is presented. The gradually increased mechanics of the sGHB patch could effectively mitigate the stress concentration at the wound edge, and also resist the wound expansion at various stages, thus mechanically contracting the chronic wounds in a programmable manner. The self-growing hydrogel patch demonstrated enhanced wound healing efficacy in a mouse diabetic wound model, by regulating the inflammatory response, promoting the faster re-epithelialization and angiogenesis through mechanical modulation. Such kind of self-growing hydrogel bioadhesives have potential clinical utility for a variety of wound management where dynamic mechanical modulation is indispensable
Beschreibung:	Date Completed 10.10.2024 Date Revised 10.10.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202408538