Deep immune cell phenotyping and induced immune cell responses at admission stratified by BMI in patients hospitalized with COVID-19 : An observational multicenter cohort pilot study

Détails bibliographiques
Publié dans:	Clinical immunology (Orlando, Fla.). - 1999. - 267(2024) vom: 06. Okt., Seite 110336
Auteur principal:	Sejdic, Adin (Auteur)
Autres auteurs:	Hartling, Hans Jakob, Gitz Holler, Jon, Klingen Gjærde, Lars, Matovu Dungu, Arnold, Engel Møller, Maria Elizabeth, Svanberg Teglgaard, Rebecca, Utoft Niemann, Carsten Utoft, Brooks, Patrick Terrence, Mogensen, Trine H, Weis, Nina, Podlekareva, Daria, Baum Jørgensen, Marie Louise, Ortved Gang, Anne, Stampe Hersby, Ditte, Hald, Annemette, Dam Nielsen, Susanne, Lebech, Anne-Mette, Helleberg, Marie, Lundgren, Jens, Træholt Franck, Kristina, Fischer, Thea K, Harboe, Zitta Barrella, Marquart, Hanne Vibeke, Rye Ostrowski, Sisse, Lindegaard, Birgitte
Format:	Article en ligne
Langue:	English
Publié:	2024
Accès à la collection:	Clinical immunology (Orlando, Fla.)
Sujets:	Journal Article Observational Study Multicenter Study Adaptive immunity B cells BMI COVID-19 Cytokines Inflammation Innate immunity plus... Obesity SARS-CoV-2 T cells


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100	1		\|a Sejdic, Adin \|e verfasserin \|4 aut
245	1	0	\|a Deep immune cell phenotyping and induced immune cell responses at admission stratified by BMI in patients hospitalized with COVID-19 \|b An observational multicenter cohort pilot study
264		1	\|c 2024
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500			\|a Date Completed 14.09.2024
500			\|a Date Revised 31.12.2024
500			\|a published: Print-Electronic
500			\|a Citation Status MEDLINE
520			\|a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
520			\|a INTRODUCTION: Overweight and obesity are linked to increased hospitalization and mortality in COVID-19 patients. This study aimed to characterize induced immune responses and deep immune cell profiles stratified by BMI in hospitalized COVID-19 patients
520			\|a METHODS AND RESULTS: This observational multicenter cohort pilot study included 122 adult patients with PCR-confirmed COVID-19 in Denmark, stratified by BMI (normal weight, overweight, obese). Inflammation was assessed using TruCulture® and immune cell profiles by flow cytometry with a customized antibody panel (DuraClone®). Patients with obesity had a more pro-inflammatory phenotype with increased TNF-α, IL-8, IL-17, and IL-10 levels post-T cell stimulation, and altered B cell profiles. Patients with obesity showed higher concentrations of naïve, transitional, and non-isotype switched memory B cells, and plasmablasts compared to normal weight patients and healthy controls
520			\|a CONCLUSIONS: Obesity in hospitalized COVID-19 patients may correlate with elevated pro-inflammatory cytokines, anti-inflammatory IL-10, and increased B cell subset activation, highlighting the need for further studies
650		4	\|a Journal Article
650		4	\|a Observational Study
650		4	\|a Multicenter Study
650		4	\|a Adaptive immunity
650		4	\|a B cells
650		4	\|a BMI
650		4	\|a COVID-19
650		4	\|a Cytokines
650		4	\|a Inflammation
650		4	\|a Innate immunity
650		4	\|a Obesity
650		4	\|a SARS-CoV-2
650		4	\|a T cells
650		7	\|a Cytokines \|2 NLM
700	1		\|a Hartling, Hans Jakob \|e verfasserin \|4 aut
700	1		\|a Gitz Holler, Jon \|e verfasserin \|4 aut
700	1		\|a Klingen Gjærde, Lars \|e verfasserin \|4 aut
700	1		\|a Matovu Dungu, Arnold \|e verfasserin \|4 aut
700	1		\|a Engel Møller, Maria Elizabeth \|e verfasserin \|4 aut
700	1		\|a Svanberg Teglgaard, Rebecca \|e verfasserin \|4 aut
700	1		\|a Utoft Niemann, Carsten Utoft \|e verfasserin \|4 aut
700	1		\|a Brooks, Patrick Terrence \|e verfasserin \|4 aut
700	1		\|a Mogensen, Trine H \|e verfasserin \|4 aut
700	1		\|a Weis, Nina \|e verfasserin \|4 aut
700	1		\|a Podlekareva, Daria \|e verfasserin \|4 aut
700	1		\|a Baum Jørgensen, Marie Louise \|e verfasserin \|4 aut
700	1		\|a Ortved Gang, Anne \|e verfasserin \|4 aut
700	1		\|a Stampe Hersby, Ditte \|e verfasserin \|4 aut
700	1		\|a Hald, Annemette \|e verfasserin \|4 aut
700	1		\|a Dam Nielsen, Susanne \|e verfasserin \|4 aut
700	1		\|a Lebech, Anne-Mette \|e verfasserin \|4 aut
700	1		\|a Helleberg, Marie \|e verfasserin \|4 aut
700	1		\|a Lundgren, Jens \|e verfasserin \|4 aut
700	1		\|a Træholt Franck, Kristina \|e verfasserin \|4 aut
700	1		\|a Fischer, Thea K \|e verfasserin \|4 aut
700	1		\|a Harboe, Zitta Barrella \|e verfasserin \|4 aut
700	1		\|a Marquart, Hanne Vibeke \|e verfasserin \|4 aut
700	1		\|a Rye Ostrowski, Sisse \|e verfasserin \|4 aut
700	1		\|a Lindegaard, Birgitte \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Clinical immunology (Orlando, Fla.) \|d 1999 \|g 267(2024) vom: 06. Okt., Seite 110336 \|w (DE-627)NLM098196855 \|x 1521-7035 \|7 nnas
773	1	8	\|g volume:267 \|g year:2024 \|g day:06 \|g month:10 \|g pages:110336
856	4	0	\|u http://dx.doi.org/10.1016/j.clim.2024.110336 \|3 Volltext
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