Ultrasound-Activated Probiotics Vesicles Coating for Titanium Implant Infections Through Bacterial Cuproptosis-Like Death and Immunoregulation

Ultrasound-Activated Probiotics Vesicles Coating for Titanium Implant Infections Through Bacterial Cuproptosis-Like Death and Immunoregulation

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 44 vom: 04. Nov., Seite e2405953
1. Verfasser: Li, Shuoyuan (VerfasserIn)
Weitere Verfasser: Yue, Yan, Wang, Wenqi, Han, Mingyue, Wan, Xufeng, Li, Qiaochu, Chen, Xiaoting, Cao, Jian, Zhang, Yangming, Li, Jiyao, Li, Jianshu, Cheng, Lei, Yang, Jiaojiao, Wang, Duan, Zhou, Zongke
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article antibacterial immunomodulation osteointegration probiotics extracellular vesicles Titanium D1JT611TNE Anti-Bacterial Agents Coated Materials, Biocompatible Copper mehr... 789U1901C5 Metal-Organic Frameworks Porphyrins
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520 |a Implant-associated infections (IAIs) are the main cause of prosthetic implant failure. Bacterial biofilms prevent antibiotic penetration, and the unique metabolic conditions in hypoxic biofilm microenvironment may limit the efficacy of conventional antibiotic treatment. Escaping survival bacteria may not be continually eradicated, resulting in the recurrence of IAIs. Herein, a sonosensitive metal-organic framework of Cu-TCPP (tetrakis(4-carboxyphenyl) porphyrin) nanosheets and tinidazole doped probiotic-derived membrane vesicles (OMVs) with high-penetration sonodynamic therapy (SDT), bacterial metabolic state interference, and bacterial cuproptosis-like death to eradicate IAIs is proposed. The Cu-TCPP can convert O2 to toxic 1O2 through SDT in the normoxic conditions, enhancing the hypoxic microenvironment and activating the antibacterial activity of tinidazole. The released Cu(II) under ultrasound can be converted to Cu(I) by exogenous poly(tannic acid) (pTA) and endogenous glutathione. The disruption of the bacterial membrane by SDT can enhance the Cu(I) transporter activity. Transcriptomics indicate that the SDT-enhanced Cu(I) overload and hypoxia-activated therapy hinder the tricarboxylic acid cycle (TCA), leading to bacterial cuproptosis-like death. Moreover, the OMVs-activated therapy can polarize macrophages to a M2-like phenotype and facilitate bone repair. The sonodynamic biofilm microenvironment modulation strategy, whereby the hypoxia-enhanced microenvironment is potentiated to synergize SDT with OMVs-activated therapy, provides an effective strategy for antibacterial and osteogenesis performance 
650 4 |a Journal Article 
650 4 |a antibacterial 
650 4 |a immunomodulation 
650 4 |a osteointegration 
650 4 |a probiotics extracellular vesicles 
650 7 |a Titanium  |2 NLM 
650 7 |a D1JT611TNE  |2 NLM 
650 7 |a Anti-Bacterial Agents  |2 NLM 
650 7 |a Coated Materials, Biocompatible  |2 NLM 
650 7 |a Copper  |2 NLM 
650 7 |a 789U1901C5  |2 NLM 
650 7 |a Metal-Organic Frameworks  |2 NLM 
650 7 |a Porphyrins  |2 NLM 
700 1 |a Yue, Yan  |e verfasserin  |4 aut 
700 1 |a Wang, Wenqi  |e verfasserin  |4 aut 
700 1 |a Han, Mingyue  |e verfasserin  |4 aut 
700 1 |a Wan, Xufeng  |e verfasserin  |4 aut 
700 1 |a Li, Qiaochu  |e verfasserin  |4 aut 
700 1 |a Chen, Xiaoting  |e verfasserin  |4 aut 
700 1 |a Cao, Jian  |e verfasserin  |4 aut 
700 1 |a Zhang, Yangming  |e verfasserin  |4 aut 
700 1 |a Li, Jiyao  |e verfasserin  |4 aut 
700 1 |a Li, Jianshu  |e verfasserin  |4 aut 
700 1 |a Cheng, Lei  |e verfasserin  |4 aut 
700 1 |a Yang, Jiaojiao  |e verfasserin  |4 aut 
700 1 |a Wang, Duan  |e verfasserin  |4 aut 
700 1 |a Zhou, Zongke  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 36(2024), 44 vom: 04. Nov., Seite e2405953  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:36  |g year:2024  |g number:44  |g day:04  |g month:11  |g pages:e2405953 
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