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240801s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.plaphy.2024.108963
|2 doi
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|a pubmed25n1251.xml
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|a (DE-627)NLM375716327
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|a (NLM)39084166
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|a (PII)S0981-9428(24)00631-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Yoo, Jae Yong
|e verfasserin
|4 aut
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| 245 |
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|a IRE1 is implicated in protein synthesis regulation under ER stress conditions in plants
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 14.09.2024
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|a Date Revised 14.09.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 Elsevier Masson SAS. All rights reserved.
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|a The unfolded protein response (UPR) is a crucial cellular mechanism for maintaining protein folding homeostasis during endoplasmic reticulum (ER) stress. In this study, the role of IRE1, a key component of the UPR, was investigated in protein translation regulation under ER stress conditions in Arabidopsis. We discovered that the loss of IRE1A and IRE1B leads to diminished protein translation, indicating a significant role for IRE1 in this process. However, this regulation was not solely dependent on the interaction with bZIP60, a key transcription factor in the UPR. Interestingly, while chemical chaperones TUDCA and PBA effectively alleviated the translation inhibition observed in ire1a ire1b mutants, this effect was more pronounced than the mitigation observed from suppressing GCN2 expression or introducing a non-phosphorylatable eIF2α variant. Additionally, the kinase and ribonuclease activities of IRE1B were demonstrated to be crucial for plant adaptation and protein synthesis regulation under ER stress conditions. Overall, this study not only highlights the complex regulatory mechanisms of IRE1 in plant ER stress responses but also provides insights into its multifaceted roles in protein translation regulation
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|a Journal Article
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|a Arabidopsis Proteins
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|a Ire1-1 protein, Arabidopsis
|2 NLM
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|a EC 2.7.1.-
|2 NLM
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|a Protein Serine-Threonine Kinases
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|a EC 2.7.11.1
|2 NLM
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|a Basic-Leucine Zipper Transcription Factors
|2 NLM
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|a bZIP60 protein, Arabidopsis
|2 NLM
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|a Ire1-2 protein, Arabidopsis
|2 NLM
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| 650 |
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|a EC 2.7.1.-
|2 NLM
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| 650 |
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|a Protein Kinases
|2 NLM
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| 650 |
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|a EC 2.7.-
|2 NLM
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| 700 |
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|a Ko, Ki Seong
|e verfasserin
|4 aut
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| 700 |
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|a Vu, Bich Ngoc
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Young Eun
|e verfasserin
|4 aut
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| 700 |
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|a Choi, Ha Na
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Yoo Na
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fanata, Wahyu Indra Duwi
|e verfasserin
|4 aut
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| 700 |
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|a Harmoko, Rikno
|e verfasserin
|4 aut
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|a Lee, Sang-Kyu
|e verfasserin
|4 aut
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|a Chung, Woo Sik
|e verfasserin
|4 aut
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|a Hong, Jong Chan
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Kyun Oh
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Plant physiology and biochemistry : PPB
|d 1991
|g 215(2024) vom: 30. Okt., Seite 108963
|w (DE-627)NLM098178261
|x 1873-2690
|7 nnas
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| 773 |
1 |
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|g volume:215
|g year:2024
|g day:30
|g month:10
|g pages:108963
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| 856 |
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|u http://dx.doi.org/10.1016/j.plaphy.2024.108963
|3 Volltext
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|d 215
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