Pyroptotic-Spatiotemporally Selective Delivery of siRNA against Pyroptosis and Autoimmune Diseases

Pyroptotic-Spatiotemporally Selective Delivery of siRNA against Pyroptosis and Autoimmune Diseases

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 38 vom: 03. Sept., Seite e2407115
1. Verfasser: Pan, Zongyou (VerfasserIn)
Weitere Verfasser: Xu, Kaiwang, Huang, Guanrui, Hu, Haoran, Yang, Huang, Shen, Haotian, Qiu, Kaijie, Wang, Canlong, Xu, Tengjing, Yu, Xinning, Fang, Jinhua, Wang, Jiajie, Lin, Yunting, Dai, Jiacheng, Zhong, Yuting, Song, Hongyun, Zhu, Sunan, Wang, Siheng, Zhou, Zhuxing, Sun, Chuyue, Tang, Zhaopeng, Liao, Shiyao, Yang, Guang, You, Zhiyuan, Dai, Xuesong, Mao, Zhengwei
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article anti‐inflammation nanomedicine pyroptosis responsive delivery targeted delivery RNA, Small Interfering Cardiolipins
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520 |a Small-interfering RNAs (siRNAs) offer promising prospects for treating pyroptosis-related autoimmune diseases. However, poor stability and off-target effects during in vivo transportation hinder their practical clinical applications. Precision delivery and adaptive release of siRNAs into inflamed tissues and immune cells could unleash their full therapeutic potential. This study establishes a pyroptotic-spatiotemporally selective siRNA delivery system (PMRCsiGSDME) that selectively targets inflammatory tissues, responds to pyroptosis, and exhibits remarkable therapeutic efficacy against various autoimmune diseases. Novel hybrid nanovesicles (NVs) are designed as a combination of pyroptotic macrophage membranes (PMs) and R8-cardiolipin-containing nanovesicles (RC-NVs). Evidence provides that PM-derived proteins involved in cell-cell interactions and membrane trafficking may contribute to the specificity of NVs to inflammatory tissue. In addition, cardiolipin anchored in the hybrid NVs increases its affinity for activated gasdermin E (GSDME) and achieves pyroptosis-adaptive release of siGSDME for the spatiotemporally selective suppression of immune responses. More importantly, PMRC@siGSDME displays significant anti-inflammatory and therapeutic effects in multiple mouse autoimmune disease models, including arthritis and inflammatory bowel disease (IBD). Collectively, an innovative siRNA delivery strategy precisely tailored for pyroptotic cells has been developed, paving the way for new treatments for autoimmune inflammatory diseases with minimal side effects and wide clinical applicability 
650 4 |a Journal Article 
650 4 |a anti‐inflammation 
650 4 |a nanomedicine 
650 4 |a pyroptosis 
650 4 |a responsive delivery 
650 4 |a targeted delivery 
650 7 |a RNA, Small Interfering  |2 NLM 
650 7 |a Cardiolipins  |2 NLM 
700 1 |a Xu, Kaiwang  |e verfasserin  |4 aut 
700 1 |a Huang, Guanrui  |e verfasserin  |4 aut 
700 1 |a Hu, Haoran  |e verfasserin  |4 aut 
700 1 |a Yang, Huang  |e verfasserin  |4 aut 
700 1 |a Shen, Haotian  |e verfasserin  |4 aut 
700 1 |a Qiu, Kaijie  |e verfasserin  |4 aut 
700 1 |a Wang, Canlong  |e verfasserin  |4 aut 
700 1 |a Xu, Tengjing  |e verfasserin  |4 aut 
700 1 |a Yu, Xinning  |e verfasserin  |4 aut 
700 1 |a Fang, Jinhua  |e verfasserin  |4 aut 
700 1 |a Wang, Jiajie  |e verfasserin  |4 aut 
700 1 |a Lin, Yunting  |e verfasserin  |4 aut 
700 1 |a Dai, Jiacheng  |e verfasserin  |4 aut 
700 1 |a Zhong, Yuting  |e verfasserin  |4 aut 
700 1 |a Song, Hongyun  |e verfasserin  |4 aut 
700 1 |a Zhu, Sunan  |e verfasserin  |4 aut 
700 1 |a Wang, Siheng  |e verfasserin  |4 aut 
700 1 |a Zhou, Zhuxing  |e verfasserin  |4 aut 
700 1 |a Sun, Chuyue  |e verfasserin  |4 aut 
700 1 |a Tang, Zhaopeng  |e verfasserin  |4 aut 
700 1 |a Liao, Shiyao  |e verfasserin  |4 aut 
700 1 |a Yang, Guang  |e verfasserin  |4 aut 
700 1 |a You, Zhiyuan  |e verfasserin  |4 aut 
700 1 |a Dai, Xuesong  |e verfasserin  |4 aut 
700 1 |a Mao, Zhengwei  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 36(2024), 38 vom: 03. Sept., Seite e2407115  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnas 
773 1 8 |g volume:36  |g year:2024  |g number:38  |g day:03  |g month:09  |g pages:e2407115 
856 4 0 |u http://dx.doi.org/10.1002/adma.202407115  |3 Volltext 
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