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240729s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110330
|2 doi
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|a pubmed24n1505.xml
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|a (NLM)39067678
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|a (PII)S1521-6616(24)00439-X
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Ekman, Ilse
|e verfasserin
|4 aut
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| 245 |
1 |
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|a The effect of early life cytomegalovirus infection on the immune profile of children
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 16.08.2024
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|a Date Revised 16.08.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Cytomegalovirus (CMV) infection has a life-long impact on the immune system, particularly on memory T cells. However, the effect of early life CMV infection on the phenotype and functionality of T cells in infants and especially longitudinal changes occurring during childhood have not been explored in detail. The phenotype and functionality of peripheral blood CD8+ and CD4+ T cells from children infected with CMV in early life (< 6 months of age) was analyzed using high-dimensional flow cytometry. Samples from CMV IgG-seropositive (CMV+) children were collected at 6 months and 6 years of age and compared to samples from CMV-seronegative (CMV-) children. Early life CMV infection caused multiple alterations within T cells. These include downregulation of CD28 expression and upregulation of CD57 expression within both CD27+ early and CD27- late effector memory CD8+ and CD4+ T-cells at 6 months of age. Of these changes, only alterations within the highly differentiated late effector memory compartment persisted at the age of 6 years. Early life CMV-infection has a distinct impact on developing CD8+ and CD4+ memory T cell compartments. It appears to induce both temporary as well as longer-lasting alterations, which may affect the functionality of the immune system throughout life
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|a Journal Article
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|a CMV
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| 650 |
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|a Human
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| 650 |
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|a Human cytomegalovirus
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| 650 |
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4 |
|a T cells
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| 650 |
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|a Viral infection
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| 650 |
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|a Tumor Necrosis Factor Receptor Superfamily, Member 7
|2 NLM
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| 650 |
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|a CD28 Antigens
|2 NLM
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| 650 |
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|a CD57 Antigens
|2 NLM
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| 650 |
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|a Immunoglobulin G
|2 NLM
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| 700 |
1 |
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|a Schroderus, Anna-Mari
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vuorinen, Tytti
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Knip, Mikael
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Veijola, Riitta
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Toppari, Jorma
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ilonen, Jorma
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lempainen, Johanna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kinnunen, Tuure
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 266(2024) vom: 26. Aug., Seite 110330
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:266
|g year:2024
|g day:26
|g month:08
|g pages:110330
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2024.110330
|3 Volltext
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