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240729s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110329
|2 doi
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|a pubmed24n1505.xml
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|a (NLM)39067679
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|a (PII)S1521-6616(24)00438-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wang, Yihan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Age-dependent decrease of circulating T follicular helper cells correlates with disease severity in elderly patients with COVID-19
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|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 16.08.2024
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|a Date Revised 16.08.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 Elsevier Inc. All rights reserved.
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|a Overwhelming evidence has shown that aging is a significant risk factor for COVID-19-related hospitalizations, death and other adverse health outcomes. Particular T cell subsets that susceptible to aging and associated with COVID-19 disease severity requires further elucidation. Our study recruited 57 elderly patients with acute COVID-19 and 27 convalescent donors. Adaptive immunity was assessed across the COVID-19 severity spectrum. Patients underwent age-dependent CD4+ T lymphopenia, preferential loss of circulating T follicular regulatory cells (cTfh) subsets including cTfh-em, cTfh-cm, cTfh1, cTfh2, cTfh17 and circulating T follicular regulatory cells (cTfr), which regulated antibody production through different pathways and correlated with COVID-19 severity, were observed. Moreover, vaccination improved cTfh-cm, cTfh2, cTfr proportion and promoted NAb production. In conclusion, the elderly had gone through age-dependent cTfh subsets deficiency, which impeded NAb production and enabled aggravation of COVID-19 to critical illness, whereas SARS-CoV-2 vaccine inoculation helped to rejuvenate cTfh, cTfr and intensify NAb responses
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4 |
|a Journal Article
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| 650 |
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|a Aging
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| 650 |
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|a COVID-19
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| 650 |
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|a Circulating T follicular helper cells
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| 650 |
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|a Elderly patients
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| 650 |
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|a Lymphopenia
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| 650 |
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|a Vaccination
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| 650 |
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|a COVID-19 Vaccines
|2 NLM
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| 650 |
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7 |
|a Antibodies, Viral
|2 NLM
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| 700 |
1 |
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|a Wang, Qiu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Furong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qiao, Nan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xuejun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wei, Liqun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Lingjin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dai, Weiqian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pang, Xueyang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Jiayi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Chuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Guangchen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pang, Chongjie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Zhidong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xing, Man
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wan, Chunxiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Dongming
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 266(2024) vom: 26. Aug., Seite 110329
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:266
|g year:2024
|g day:26
|g month:08
|g pages:110329
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2024.110329
|3 Volltext
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