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240726s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202406652
|2 doi
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|a eng
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| 100 |
1 |
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|a Kwon, Jinju
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Engineered Regenerative Isolated Peripheral Nerve Interface for Targeted Reinnervation
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|c 2024
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|a Text
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|a ƒaComputermedien
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|a Date Completed 01.11.2024
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|a Date Revised 01.11.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a A regenerative peripheral nerve interface (RPNI) offers a therapeutic solution for nerve injury through reconstruction of the target muscle. However, implanting a transected peripheral nerve into an autologous skeletal muscle graft in RPNI causes donor-site morbidity, highlighting the need for tissue-engineered skeletal muscle constructs. Here, an engineered regenerative isolated peripheral nerve interface (eRIPEN) is developed using 3D skeletal cell printing combined with direct electrospinning to create a nanofiber membrane envelop for host nerve implantation. In this in vivo study, after over 8 months of RPNI surgery, the eRIPEN exhibits a minimum Feret diameter of 15-20 µm with a cross-sectional area of 100-500 µm2, representing the largest distribution of myofibers. Furthermore, neuromuscular junction formation and muscle contraction with a force of ≈28 N are observed. Notably, the decreased hypersensitivity to mechanical/thermal stimuli and an improved tibial functional index from -77 to -56 are found in the eRIPEN group. The present novel concept of eRIPEN paves the way for the utilization and application of tissue-engineered constructs in RPNI, ultimately realizing neuroprosthesis control through synaptic connections
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|a Journal Article
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|a 3D bioprinting
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|a decellularized extracellular matrix
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| 650 |
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4 |
|a nanofiber membrane
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| 650 |
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|a regenerative peripheral nerve interface
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| 650 |
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|a reinnervation
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| 650 |
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4 |
|a tissue engineering
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| 700 |
1 |
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|a Eom, Seongsu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kong, Jeong Sik
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cho, Dong-Woo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Dong Sung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Junesun
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 44 vom: 24. Nov., Seite e2406652
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|g volume:36
|g year:2024
|g number:44
|g day:24
|g month:11
|g pages:e2406652
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|u http://dx.doi.org/10.1002/adma.202406652
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