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|a 10.1002/adma.202406434
|2 doi
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|a eng
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|a Xie, Qingqiao
|e verfasserin
|4 aut
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| 245 |
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|a In Situ Triggered Self-Contraction Bioactive Microgel Assembly Accelerates Diabetic Skin Wound Healing by Activating Mechanotransduction and Biochemical Pathway
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|c 2024
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 03.10.2024
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|a Date Revised 03.10.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Chronic nonhealing skin wounds, characterized by reduced tissue contractility and inhibited wound cell survival under hyperglycemia and hypoxia, present a significant challenge in diabetic care. Here, an advanced self-contraction bioactive core-shell microgel assembly with robust tissue-adhesion (SMART-EXO) is introduced to expedite diabetic wound healing. The SMART-EXO dressing exhibits strong, reversible adhesion to damaged tissue due to abundant hydrogen and dynamic coordination bonds. Additionally, the core-shell microgel components and dynamic coordination bonds provide moderate rigidity, customizable self-contraction, and an interlinked porous architecture. The triggered in situ self-contraction of the SMART-EXO dressing enables active, tunable wound contraction, activating mechanotransduction in the skin and promoting the optimal fibroblast-to-myofibroblast conversion, collagen synthesis, and angiogenesis. Concurrently, the triggered contraction of SMART-EXO facilitates efficient loading and on-demand release of bioactive exosomes, contributing to re-epithelialization and wound microenvironment regulation in diabetic mice. RNA-seq results reveal the activation of critical signaling pathways associated with mechanosensing and exosome regulation, highlighting the combined biomechanical and biochemical mechanisms. These findings underscore SMART-EXO as a versatile, adaptable solution to the complex challenges of diabetic wound care
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a biomechanical and biochemical cues
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| 650 |
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4 |
|a core–shell microgel assembly
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| 650 |
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4 |
|a diabetic wound healing
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| 650 |
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4 |
|a exosome delivery
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| 650 |
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4 |
|a self‐contraction
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| 650 |
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7 |
|a Gels
|2 NLM
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| 650 |
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7 |
|a Biocompatible Materials
|2 NLM
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| 700 |
1 |
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|a Yan, Chenchen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Guohui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bian, Liming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Kunyu
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 38 vom: 23. Sept., Seite e2406434
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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|g volume:36
|g year:2024
|g number:38
|g day:23
|g month:09
|g pages:e2406434
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|u http://dx.doi.org/10.1002/adma.202406434
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