In Situ Triggered Self-Contraction Bioactive Microgel Assembly Accelerates Diabetic Skin Wound Healing by Activating Mechanotransduction and Biochemical Pathway

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 38 vom: 23. Sept., Seite e2406434
1. Verfasser: Xie, Qingqiao (VerfasserIn)
Weitere Verfasser: Yan, Chenchen, Liu, Guohui, Bian, Liming, Zhang, Kunyu
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article biomechanical and biochemical cues core–shell microgel assembly diabetic wound healing exosome delivery self‐contraction Gels Biocompatible Materials
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520 |a Chronic nonhealing skin wounds, characterized by reduced tissue contractility and inhibited wound cell survival under hyperglycemia and hypoxia, present a significant challenge in diabetic care. Here, an advanced self-contraction bioactive core-shell microgel assembly with robust tissue-adhesion (SMART-EXO) is introduced to expedite diabetic wound healing. The SMART-EXO dressing exhibits strong, reversible adhesion to damaged tissue due to abundant hydrogen and dynamic coordination bonds. Additionally, the core-shell microgel components and dynamic coordination bonds provide moderate rigidity, customizable self-contraction, and an interlinked porous architecture. The triggered in situ self-contraction of the SMART-EXO dressing enables active, tunable wound contraction, activating mechanotransduction in the skin and promoting the optimal fibroblast-to-myofibroblast conversion, collagen synthesis, and angiogenesis. Concurrently, the triggered contraction of SMART-EXO facilitates efficient loading and on-demand release of bioactive exosomes, contributing to re-epithelialization and wound microenvironment regulation in diabetic mice. RNA-seq results reveal the activation of critical signaling pathways associated with mechanosensing and exosome regulation, highlighting the combined biomechanical and biochemical mechanisms. These findings underscore SMART-EXO as a versatile, adaptable solution to the complex challenges of diabetic wound care 
650 4 |a Journal Article 
650 4 |a biomechanical and biochemical cues 
650 4 |a core–shell microgel assembly 
650 4 |a diabetic wound healing 
650 4 |a exosome delivery 
650 4 |a self‐contraction 
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650 7 |a Biocompatible Materials  |2 NLM 
700 1 |a Yan, Chenchen  |e verfasserin  |4 aut 
700 1 |a Liu, Guohui  |e verfasserin  |4 aut 
700 1 |a Bian, Liming  |e verfasserin  |4 aut 
700 1 |a Zhang, Kunyu  |e verfasserin  |4 aut 
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