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240722s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110322
|2 doi
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|a pubmed24n1549.xml
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|a (PII)S1521-6616(24)00431-5
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Feng, Kangni
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Novel insight into MDA-7/IL-24
|b A potent therapeutic target for autoimmune and inflammatory diseases
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|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 16.08.2024
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|a Date Revised 26.09.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024. Published by Elsevier Inc.
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|a Melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24) is a pleiotropic member of the IL-10 family of cytokines, and is involved in multiple biological processes, including cell proliferation, cell differentiation, tissue fibrosis, the inflammatory response, and antitumor activity. MDA-7/IL-24 can regulate epithelial integrity, homeostasis, mucosal immunity and host resistance to various pathogens by enhancing immune and inflammatory responses. Our recent study revealed the mechanism of MDA-7/IL-24 in promoting airway inflammation and airway remodeling through activating the JAK/STAT3 and ERK signaling pathways in bronchial epithelial cells. Herein, we summarize the cellular sources, inducers, target cells, signaling pathways, and biological effects of MDA-7/IL-24 in several allergic and autoimmune diseases. This review also synopsizes recent advances in clinical research targeting MDA-7/IL-24 or its receptors. Based on these advancements, we emphasize its potential as a target for immunotherapy and discuss the challenges of developing immunotherapeutic drugs targeting MDA-7/IL-24 or its receptors in autoimmune and inflammatory disorders
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|a Journal Article
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| 650 |
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|a Review
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4 |
|a Allergy
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| 650 |
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|a Autoimmune diseases
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| 650 |
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4 |
|a Inflammation
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| 650 |
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|a MDA-7/IL-24
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| 650 |
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|a interleukin-24
|2 NLM
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| 650 |
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7 |
|a Interleukins
|2 NLM
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| 700 |
1 |
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|a Cen, Jiemei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zou, Xiaoling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Tiantuo
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 266(2024) vom: 27. Sept., Seite 110322
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:266
|g year:2024
|g day:27
|g month:09
|g pages:110322
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2024.110322
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