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240718s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.4c01909
|2 doi
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|a eng
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|a Lao, Min
|e verfasserin
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|a Effect of Specific Surface Area and Hydrophobicity of Electrospun Nanofibers on the Sustained Release Performance of Diclofenac Sodium
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|c 2024
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|a Text
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|a Date Revised 17.07.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a Nanofibers produced by electrospinning are suitable options for slow-release materials. Diclofenac sodium (DS) is a nonsteroidal anti-inflammatory medication with a brief half-life that can serve as an effective sustained-release agent. This paper presents a novel method for producing DS-sustained release nanofibers by electrostatic spinning processes. During the preparation, the slow-release capabilities of biodegradable materials poly(lactic acid) (PLA) and polycaprolactone (PCL) are investigated. A composite drug-carrying scaffold is prepared to enhance the sustained-release performance. The sustained release ability is affected by the specific surface area of the nanofibers and the hydrophobicity of the polymer. The findings indicate that the composite nanofiber with a PLA/PCL ratio of 1:1 demonstrates the most effective sustained-release performance. The release rate is mostly influenced by the hydrophobicity of the polymer at this point. Sustained-release kinetic simulations were performed and revealed that the release of nanofibers follows a first-order release paradigm. This work presents a straightforward approach for creating a sustained-release formulation of DS
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|a Journal Article
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|a Wang, Yingjie
|e verfasserin
|4 aut
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|a Li, Xin
|e verfasserin
|4 aut
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|a Li, Junlang
|e verfasserin
|4 aut
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1 |
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|a Ning, Xin
|e verfasserin
|4 aut
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|a Yin, Shaofeng
|e verfasserin
|4 aut
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|a Deng, Xiaoting
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g (2024) vom: 17. Juli
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|x 1520-5827
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|g year:2024
|g day:17
|g month:07
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|u http://dx.doi.org/10.1021/acs.langmuir.4c01909
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