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20241015232151.0 |
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240716s2024 xx |||||o 00| ||eng c |
| 024 |
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|a 10.1111/jfd.14001
|2 doi
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|a pubmed24n1568.xml
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|a (DE-627)NLM374993467
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|a (NLM)39011626
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Knutsen, Ingrid Svihus
|e verfasserin
|4 aut
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| 245 |
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|a Inflammatory responses in Atlantic lumpfish (Cyclopterus lumpus L.) after intraperitoneal injection of a vaccine against Aeromonas salmonicida and Vibrio salmonicida at different water temperatures
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.10.2024
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|a Date Revised 14.10.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 The Author(s). Journal of Fish Diseases published by John Wiley & Sons Ltd.
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|a Studying inflammatory responses induced by vaccination can contribute to a more detailed understanding of underlying immune mechanisms in lumpfish (Cyclopterus lumpus). Tissue samples from lumpfish intraperitoneally immunized with a divalent oil-adjuvanted vaccine (Aeromonas salmonicida and Vibrio salmonicida) at water temperatures of 5, 10, and 15°C were collected at 630 day degrees and 18 weeks post injection. The relative amount of secretory and membrane-bound immunoglobulin M (IgM) gene transcripts in the head kidney was determined by qPCR. Vaccine-induced inflammatory lesions were assessed on histological sections of abdominal pancreatic/intestinal tissue from vaccinated fish in all three temperature groups. Inflammatory cells forming dense aggregations in lesions showed proliferative activity, many of which were identified as eosinophilic-granulocyte-like cells. IgM+ cells were scattered in inflammatory tissue dominated by connective tissue, showing no difference in numbers between lesions from fish vaccinated at 5, 10, and 15°C. Relative gene expression analysis of secretory and membrane-bound IgM revealed low overall expression in the head kidney of vaccinated fish at both 630 day-degrees and 18 weeks post injection. The results of this study indicate that the vaccine stimulated prolonged local inflammatory responses at the injection site, which were not influenced by temperature
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| 650 |
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4 |
|a Journal Article
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| 650 |
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|a Aeromonas salmonicida
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| 650 |
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4 |
|a Atlantic lumpfish
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| 650 |
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|a immune response
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| 650 |
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4 |
|a temperature
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| 650 |
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4 |
|a vaccine
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| 650 |
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|a Bacterial Vaccines
|2 NLM
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| 650 |
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|a Immunoglobulin M
|2 NLM
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| 700 |
1 |
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|a Erkinharju, Toni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bøgwald, Jarl
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dalmo, Roy A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Seternes, Tore
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 47(2024), 11 vom: 15. Okt., Seite e14001
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnns
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| 773 |
1 |
8 |
|g volume:47
|g year:2024
|g number:11
|g day:15
|g month:10
|g pages:e14001
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| 856 |
4 |
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|u http://dx.doi.org/10.1111/jfd.14001
|3 Volltext
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| 912 |
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|a GBV_ILN_350
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|a AR
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|d 47
|j 2024
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