Differentiation of regioisomeric N-alkylation of some indazoles and pyrazolopyridines by advanced NMR techniques
© 2024 John Wiley & Sons Ltd.
| Publié dans: | Magnetic resonance in chemistry : MRC. - 1985. - 62(2024), 11 vom: 11. Nov., Seite 765-774 |
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| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2024
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| Accès à la collection: | Magnetic resonance in chemistry : MRC |
| Sujets: | Letter 1H–15N HMBC NOESY indazole (1,2‐benzodiazole) pyrazolo[3,4‐b]pyridine pyrazolo[4,3‐b]pyridine regioisomers |
| Résumé: | © 2024 John Wiley & Sons Ltd. Indazole scaffold have two interconvertible tautomeric forms. Regioselectivities were determined for N-benzylations and alkylation of some non-substituted and substituted indazoles, under basic conditions (K2CO3) in DMF. The ratio of regioisomers occurrence between N1:N2 is almost equal. Their structures were established through a combination of NOESY and 1H-13C/15N HMBC NMR methods. Additionally, pyrazolo[3,4-b]pyridines have also three possible tautomeric forms; primarily 1H and 2H, with 7H isomers being rare. Pyrazolo[4,3-b]pyridines have only known two possible tautomeric forms so far; 1H and 2H |
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| Description: | Date Revised 02.10.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.5471 |